Neuroimaging in aphasia treatment research: Standards for establishing the effects of treatment

Kiran, Swathi, Ansaldo, Ana, Bastiaanse, Roelien, Cherney, Leora R., Howard, David, Faroqi-Shah, Yasmeen, Meinzer, Marcus and Thompson, Cynthia K. (2013) Neuroimaging in aphasia treatment research: Standards for establishing the effects of treatment. Neuroimage, 76 1: 428-435. doi:10.1016/j.neuroimage.2012.10.011


Author Kiran, Swathi
Ansaldo, Ana
Bastiaanse, Roelien
Cherney, Leora R.
Howard, David
Faroqi-Shah, Yasmeen
Meinzer, Marcus
Thompson, Cynthia K.
Title Neuroimaging in aphasia treatment research: Standards for establishing the effects of treatment
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2013-08-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neuroimage.2012.10.011
Volume 76
Issue 1
Start page 428
End page 435
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2014
Language eng
Abstract The goal of this paper is to discuss experimental design options available for establishing the effects of treatment in studies that aim to examine the neural mechanisms associated with treatment-induced language recovery in aphasia, using functional magnetic resonance imaging (fMRI). We present both group and single-subject experimental or case-series design options for doing this and address advantages and disadvantages of each. We also discuss general components of and requirements for treatment research studies, including operational definitions of variables, criteria for defining behavioral change and treatment efficacy, and reliability of measurement. Important considerations that are unique to neuroimaging-based treatment research are addressed, pertaining to the relation between the selected treatment approach and anticipated changes in language processes/functions and how such changes are hypothesized to map onto the brain.
Keyword Aphasia
Language recovery
fMRI
Treatment efficacy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Non HERDC
 
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