Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation

Meinzer, Marcus, Antonenko, Daria, Lindenberg, Robert, Hetzer, Stefan, Ulm, Lena, Avirame, Keren, Flaisch, Tobias and Floeel, Agnes (2012) Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation. Journal of Neuroscience, 32 5: 1859-1866. doi:10.1523/JNEUROSCI.4812-11.2012

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Author Meinzer, Marcus
Antonenko, Daria
Lindenberg, Robert
Hetzer, Stefan
Ulm, Lena
Avirame, Keren
Flaisch, Tobias
Floeel, Agnes
Title Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
1529-2401
Publication date 2012-02
Year available 2012
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4812-11.2012
Open Access Status File (Publisher version)
Volume 32
Issue 5
Start page 1859
End page 1866
Total pages 8
Place of publication Washington, DC United States
Publisher Society for Neuroscience
Collection year 2012
Language eng
Formatted abstract
Excitatory anodal transcranial direct current stimulation (atDCS) can improve human cognitive functions, but neural underpinnings of its mode of action remain elusive. In a cross-over placebo (“sham”) controlled study we used functional magnetic resonance imaging (fMRI) to investigate neurofunctional correlates of improved language functions induced by atDCS over a core language area, the left inferior frontal gyrus (IFG). Intrascanner transcranial direct current stimulation-induced changes in overt semantic word generation assessed behavioral modulation; task-related and task-independent (resting-state) fMRI characterized language network changes. Improved word-retrieval during atDCS was paralleled by selectively reduced task-related activation in the left ventral IFG, an area specifically implicated in semantic retrieval processes. Under atDCS, resting-state fMRI revealed increased connectivity of the left IFG and additional major hubs overlapping with the language network. In conclusion, atDCS modulates endogenous low-frequency oscillations in a distributed set of functionally connected brain areas, possibly inducing more efficient processing in critical task-relevant areas and improved behavioral performance. 
Keyword Healthy Individuals
Prefrontal Cortex
Low Frequency
Language
Networks
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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