Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia

Meinzer, Marcus, Mohammadi, Siawoosh, Kugel, Harald, Schiffbauer, Hagen, Floeel, Agnes, Albers, Johannes, Kramer, Kira, Menke, Ricarda, Baumgaertner, Annette, Knecht, Stefan, Breitenstein, Caterina and Deppe, Michael (2010) Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia. Neuroimage, 53 1: 283-290. doi:10.1016/j.neuroimage.2010.06.004


Author Meinzer, Marcus
Mohammadi, Siawoosh
Kugel, Harald
Schiffbauer, Hagen
Floeel, Agnes
Albers, Johannes
Kramer, Kira
Menke, Ricarda
Baumgaertner, Annette
Knecht, Stefan
Breitenstein, Caterina
Deppe, Michael
Title Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2010-10
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2010.06.004
Open Access Status
Volume 53
Issue 1
Start page 283
End page 290
Total pages 8
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Collection year 2010
Language eng
Formatted abstract
Aphasia after middle cerebral artery (MCA) stroke shows highly variable degrees of recovery. One possible explanation may be offered by the variability of the occlusion location. Branches from the proximal portion of the MCA often supply the mesial temporal lobe including parts of the hippocampus, a structure known to be involved in language learning. Therefore, we assessed whether language recovery in chronic aphasia is dependent on the proximity of the MCA infarct and correlated with the integrity of the hippocampus and its surrounding white matter. Language reacquisition capability was determined after 2 weeks of intensive language therapy and 8 months after treatment in ten chronic aphasia patients. Proximity of MCA occlusion relative to the internal carotid artery was determined by magnetic resonance imaging (MRI) based on the most proximal anatomical region infarcted. Structural damage to the hippocampus was assessed by MRI-based volumetry, regional microstructural integrity of hippocampus adjacent white matter by fractional anisotropy. Language learning success for trained materials was correlated with the proximity of MCA occlusion, microstructural integrity of the left hippocampus and its surrounding white matter, but not with lesion size, overall microstructural brain integrity and a control region outside of the MCA territory. No correlations were found for untrained language materials, underlining the specificity of our results for training-induced recovery. Our results suggest that intensive language therapy success in chronic aphasia after MCA stroke is critically dependent on damage to the hippocampus and its surrounding structures.
Keyword Medial Temporal Lobe
Naming Therapy
Brain
Stroke
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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