Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors

Spiller, Cassy M., Bowles, Josephine and Koopman, Peter (2013) Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors. International Journal of Developmental Biology, 57 2-4: 211-219. doi:10.1387/ijdb.130028pk


Author Spiller, Cassy M.
Bowles, Josephine
Koopman, Peter
Title Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors
Journal name International Journal of Developmental Biology   Check publisher's open access policy
ISSN 0214-6282
1696-3547
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1387/ijdb.130028pk
Volume 57
Issue 2-4
Start page 211
End page 219
Total pages 9
Place of publication Bilbao, Spain
Publisher Universidad del Pais Vasco, Servicio Editorial
Collection year 2014
Language eng
Subject 1309 Developmental Biology
2710 Embryology
Abstract Testicular cancer is the most frequent cancer in young men aged 15-40 years and ac-counts for 1% of all cancer diagnosed in males. Testicular germ cell tumors (TGCT) encompass a broad group of cancers, each displaying different levels of pluripotency and differentiation as well as malignancy potential. The TGCT cell of origin is thought to be a fetal germ cell that failed to cor-rectly differentiate during development: this is known as the 'fetal origins hypothesis'. This theory predicts that developmental pathways that control germ cell pluripotency or differentiation may be involved in the malignant transformation of these cells. Recently the Nodal/Cripto signaling pathway, known to control pluripotency and differentiation in embryonic stem (ES) cells, was implicated in regulating normal male fetal germ cell pluripotency. Although genes of this pathway are not normally expressed in germ cells during adult life, ectopic expression of this pathway was detected in several sub-groups of TGCTs. In this review, we consider the evidence for the fetal origins of TGCT and discuss the implications of Nodal/Cripto signaling in various aspects of germ cell development and cancer progression.
Keyword Cripto
Germ cell
Nodal
Testicular germ cell tumor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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Created: Thu, 31 Oct 2013, 15:45:58 EST by Susan Allen on behalf of Scholarly Communication and Digitisation Service