Quality of life of young adults and adolescents with chronic kidney disease

Tong, Allison, Wong, Germaine, McTaggart, Steve, Henning, Paul, Mackie, Fiona, Carroll, Robert P., Howard, Kirsten and Craig, Jonathan C. (2013) Quality of life of young adults and adolescents with chronic kidney disease. Journal of Pediatrics, 163 4: 1179-1185.e5. doi:10.1016/j.jpeds.2013.04.066

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Author Tong, Allison
Wong, Germaine
McTaggart, Steve
Henning, Paul
Mackie, Fiona
Carroll, Robert P.
Howard, Kirsten
Craig, Jonathan C.
Title Quality of life of young adults and adolescents with chronic kidney disease
Journal name Journal of Pediatrics   Check publisher's open access policy
ISSN 0022-3476
1097-6833
Publication date 2013-10
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jpeds.2013.04.066
Open Access Status
Volume 163
Issue 4
Start page 1179
End page 1185.e5
Total pages 12
Place of publication Philadelphia, PA, United States
Publisher Mosby
Collection year 2014
Language eng
Formatted abstract
Objective
To elicit utility-based quality of life (QOL) in adolescents and young adults with chronic kidney disease (CKD).

Study design
A cross-sectional study was conducted among patients aged 12-25 years with CKD stage 3-5 and 5D from 6 centers in Australia. QOL was measured using a visual analogue scale, and 3 utility-based QOL measures: Health Utilities Index Mark 2 and 3 (HUI2/3), Kidney Disease Quality of Life, incorporating the short form (SF)-12 transformed to SF-6D, and time trade-off (TTO). Multiple linear regression was used to define predictors for TTO QOL weights, SF-6D, and visual analogue scale scores.

Results
On a utility scale, with extremes of 0 (death) to 1 (full health), the 27 participants had a mean TTO QOL weight of 0.59 (SD = 0.40), HUI2 of 0.73 (SD = 0.28), HUI3 of 0.74 (SD = 0.26), and SF-6D of 0.70 (SD = 0.14). QOL weights were consistently low across the 4 utility-based instruments with widest variability in TTO responses. Mean QOL weights were higher among predialysis participants. The HUI2 indicated variability in the domain of emotion. From the Kidney Disease Quality of Life measures, decrements were observed in all QOL domains though dialysis patients reported a significantly higher burden attributed to kidney disease.

Conclusions
Adolescent and young adults with CKD report low QOL values. Their utility-based QOL scores imply they are willing to trade considerable life expectancy for perfect health. Holistic care to improve QOL and minimize disease burden are imperative for optimizing health outcomes in young people with CKD, particularly those on dialysis.
Keyword Chronic kidney disease (CKD)
Dialysis
Children
Health utilities index
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2014 Collection
School of Medicine Publications
 
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Created: Sun, 27 Oct 2013, 00:14:48 EST by System User on behalf of Paediatrics & Child Health - RBWH