Renal biomarkers predict nephrotoxicity after paraquat

Wunnapuk, Klintean, Liu, Xin, Peake, Philip, Gobe, Glenda, Endre, Zoltan, Grice, Jeffrey E., Roberts, Michael S. and Buckley, Nicholas A. (2013) Renal biomarkers predict nephrotoxicity after paraquat. Toxicology Letters, 222 3: 280-288. doi:10.1016/j.toxlet.2013.08.003


Author Wunnapuk, Klintean
Liu, Xin
Peake, Philip
Gobe, Glenda
Endre, Zoltan
Grice, Jeffrey E.
Roberts, Michael S.
Buckley, Nicholas A.
Title Renal biomarkers predict nephrotoxicity after paraquat
Journal name Toxicology Letters   Check publisher's open access policy
ISSN 0378-4274
1879-3169
Publication date 2013-10
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.toxlet.2013.08.003
Volume 222
Issue 3
Start page 280
End page 288
Total pages 9
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Paraquat is a widely used herbicide which has been involved in many accidental and intentional deaths. Nephrotoxicity is common in severe acute paraquat poisoning. We examined seven renal injury biomarkers, including cystatin-C, kidney injury molecule-1, β2-microglobulin, clusterin, albumin, neutrophil gelatinase-associated lipocalin and osteopontin, to develop a non-invasive method to detect early renal damage and dysfunction and to compare with the conventional endogenous marker creatinine. Male Wistar rats were dosed orally with four different doses of paraquat, and the biomarker patterns in urine and plasma were investigated at 8, 24 and 48 h after paraquat exposure. By Receiver Operating Characteristic analysis, urinary kidney injury molecule-1 was the best marker at predicting histological changes, with areas under the Receiver Operating Characteristic curve of 0.81 and 0.98 at 8 and 24 h (best cut-off value > 0.000326 μg/ml), respectively. Urinary kidney injury molecule-1, urinary albumin and urinary Cystatin-C elevations correlated with the degree of renal damage and injury development. Further study is required to compare biomarkers changes in rats with those seen in human poisoning.
Keyword Paraquat
Acute kidney injury
Renal biomarker
Creatinine
Kidney injury molecule-1
Cystatin-C
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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