Increased risk of colon cancer in men in the pre-diabetes phase

Onitilo, Adedayo A., Berg, Richard L., Engel, Jessica M., Glurich, Ingrid, Stankowski, Rachel V., Williams, Gail and Doi, Suhail A. (2013) Increased risk of colon cancer in men in the pre-diabetes phase. PloS One, 8 8: . doi:10.1371/journal.pone.0070426

Author Onitilo, Adedayo A.
Berg, Richard L.
Engel, Jessica M.
Glurich, Ingrid
Stankowski, Rachel V.
Williams, Gail
Doi, Suhail A.
Title Increased risk of colon cancer in men in the pre-diabetes phase
Journal name PloS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-08-02
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0070426
Open Access Status DOI
Volume 8
Issue 8
Total pages 10
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2014
Language eng
Formatted abstract
Background: Historically, studies exploring the association between type 2 diabetes mellitus (DM) and cancer lack accurate definition of date of DM onset, limiting temporal analyses. We examined the temporal relationship between colon cancer risk and DM using an electronic algorithm and clinical, administrative, and laboratory data to pinpoint date of DM onset.
Methods: Subjects diagnosed with DM (N = 11,236) between January 1, 1995 and December 31, 2009 were identified and matched at a 5:1 ratio with 54 365 non-diabetic subjects by age, gender, smoking history, residence, and diagnosis reference date. Colon cancer incidence relative to the reference date was used to develop Cox regression models adjusted for matching variables, body mass index, insurance status, and comorbidities. Primary outcomes measures included hazard ratio (HR) and number needed to be exposed for one additional person to be harmed (NNEH).
Results: The adjusted HR for colon cancer in men before DM onset was 1.28 (95% CI 1.04–1.58, P = 0.0223) and the NNEH decreased with time, reaching 263 at DM onset. No such difference was observed in women. After DM onset, DM did not appear to alter colon cancer risk in either gender.
Conclusions: Colon cancer risk is increased in diabetic men, but not women, before DM onset. DM did not alter colon cancer risk in men or women after clinical onset. In pre-diabetic men, colon cancer risk increased as time to DM onset decreased, suggesting that the effects of the pre-diabetes phase on colon cancer risk in men are cumulative.
Keyword Type 2 diabetes mellitus
Colorectal cancer
Screening colonoscopy
Sex hormones
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # e70426

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
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