Atrial Fibrillation in the 21st Century: A Current Understanding of Risk Factors and Primary Prevention Strategies

Menezes, Arthur R., Lavie, Carl J., DiNicolantonio, James J., O'Keefe, James, Morin, Daniel P., Khatib, Sammy and Milani, Richard V. (2013) Atrial Fibrillation in the 21st Century: A Current Understanding of Risk Factors and Primary Prevention Strategies. Mayo Clinic Proceedings, 88 4: 394-409. doi:10.1016/j.mayocp.2013.01.022

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Author Menezes, Arthur R.
Lavie, Carl J.
DiNicolantonio, James J.
O'Keefe, James
Morin, Daniel P.
Khatib, Sammy
Milani, Richard V.
Title Atrial Fibrillation in the 21st Century: A Current Understanding of Risk Factors and Primary Prevention Strategies
Journal name Mayo Clinic Proceedings   Check publisher's open access policy
ISSN 0025-6196
1942-5546
Publication date 2013-04
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.mayocp.2013.01.022
Open Access Status
Volume 88
Issue 4
Start page 394
End page 409
Total pages 16
Place of publication New York, United States
Publisher Elsevier Inc
Collection year 2014
Language eng
Formatted abstract
Atrial fibrillation (AF) is the most common arrhythmia worldwide, and it has a significant effect on morbidity and mortality. It is a significant risk factor for stroke and peripheral embolization, and it has an effect on cardiac function. Despite widespread interest and extensive research on this topic, our understanding of the etiology and pathogenesis of this disease process is still incomplete. As a result, there are no set primary preventive strategies in place apart from general cardiology risk factor prevention goals. It seems intuitive that a better understanding of the risk factors for AF would better prepare medical professionals to initially prevent or subsequently treat these patients. In this article, we discuss widely established risk factors for AF and explore newer risk factors currently being investigated that may have implications in the primary prevention of AF. For this review, we conducted a search of PubMed and used the following search terms (or a combination of terms): atrial fibrillation, metabolic syndrome, obesity, dyslipidemia, hypertension, type 2 diabetes mellitus, omega-3 fatty acids, vitamin D, exercise toxicity, alcohol abuse, and treatment. We also used additional articles that were identified from the bibliographies of the retrieved articles to examine the published evidence for the risk factors of AF.
Keyword Obstructive Sleep-Apnea
Polyunsaturated Fatty-Acids
Vitamin-D Deficiency
Renin-Angiotensin System
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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