Effect of Low Dose Dopamine Infusion On Renal Function in Acute Decompensated Heart Failure Patients Treated with Intravenous Furosemide

Peters, M. N., Alkadri, M. E., Katz, M. J. and Ventura, H. O. (2013). Effect of Low Dose Dopamine Infusion On Renal Function in Acute Decompensated Heart Failure Patients Treated with Intravenous Furosemide. In: Southern Regional Meeting of the American-Federation-for-Medical-Research, New Orleans La, (373-373). Feb 21-23, 2013.

Author Peters, M. N.
Alkadri, M. E.
Katz, M. J.
Ventura, H. O.
Title of paper Effect of Low Dose Dopamine Infusion On Renal Function in Acute Decompensated Heart Failure Patients Treated with Intravenous Furosemide
Conference name Southern Regional Meeting of the American-Federation-for-Medical-Research
Conference location New Orleans La
Conference dates Feb 21-23, 2013
Journal name Journal of Investigative Medicine   Check publisher's open access policy
Place of Publication Philadelphia, United States
Publisher Lippincott Williams & Wilkins
Publication Year 2013
Year available 2013
Sub-type Published abstract
Open Access Status
ISSN 1081-5589
1708-8267
Volume 61
Issue 2
Start page 373
End page 373
Total pages 1
Language eng
Formatted Abstract/Summary
Purpose of Study: Worsening renal function (WRF) is common in patients hospitalized with acute decompensated heart failure (ADHF) and is associated with intravenous (IV) furosemide diuresis. Recently it has been shown that addition of low dose dopamine to low-dose furosemide decreased the incidence of WRF while the diuresis remained clinically effective. The effect of dopamine on renal function in patients with ADHF and chronic kidney disease (CKD) is unknown.

Methods Used: Consecutive patients with a history of congestive heart failure, baseline ejection fraction <= 35% and glomerular filtration rate <60 mL min-1 presenting with ADHF were retrospectively assessed. All patients received >=120mg IV furosemide/24 hours for >=48 hours. Three cohorts were established based on physician-initiated therapy: (1) low dose dopamine (2-5 µg kg-1 min-1) initiated < 6 hours after presentation (Jan 2010-Jan 2012), (2) low dose dopamine initiated > 24 hours after presentation (Jan 2010- Jan 2012) and (3) no dopamine (Jan 2010-July 2010).

Summary of Results: Patients who received dopamine during hospitalization for ADHF had a significantly decreased incidence of WRF and duration of hospitalization and a non-significant increase in 30 day rehospitalization and 6 month mortality (Table). Timing of dopamine administration did not have a significant effect.

Conclusions: Among patients with CKD admitted for ADHF the addition of low dose dopamine to intravenous furosemide significantly decreased occurrence of WRF and length of hospitalization.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Fri, 18 Oct 2013, 18:57:52 EST by System User on behalf of School of Medicine