Age-related dedifferentiation and compensatory changes in the functional network underlying face processing

Burianová, Hana, Lee, Yunjo, Grady, Cheryl L. and Moscovitch, Morris (2013) Age-related dedifferentiation and compensatory changes in the functional network underlying face processing. Neurobiology of Aging, 34 12: 2759-2767. doi:10.1016/j.neurobiolaging.2013.06.016


Author Burianová, Hana
Lee, Yunjo
Grady, Cheryl L.
Moscovitch, Morris
Title Age-related dedifferentiation and compensatory changes in the functional network underlying face processing
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 0197-4580
1558-1497
Publication date 2013-12
Sub-type Article (original research)
DOI 10.1016/j.neurobiolaging.2013.06.016
Volume 34
Issue 12
Start page 2759
End page 2767
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Recent evidence has shown that older adults fail to show adaptation in the right fusiform gyrus (FG) to the same face presented repeatedly, despite accurate detection of the previously presented face. We used functional magnetic resonance imaging to investigate whether this phenomenon is associated with age-related reductions in face specificity in brain activity and whether older adults compensate for these face-processing deficiencies by increasing activity in other areas within the face-processing network, or outside this network. A comparison of brain activity across multiple stimulus categories showed that, unlike young adults who engaged a number of brain regions specific to face processing, older adults generalized these patterns of activity to objects and houses. Also, young adults showed functional connectivity between the right FG and its homologous region during face processing, whereas older adults did not engage the left FG but showed a functional connection between the right FG and left orbitofrontal cortex. Finally, this frontotemporal functional connection was activated more strongly in older adults who performed better on a face-matching task (done outside of the scanner), suggesting increased involvement of this functional link for successful face recognition with increasing age. These findings suggest that 2 neural mechanisms, dedifferentiation and compensatory neural recruitment, underlie age differences in face processing.
Keyword Aging
Face processing
fMRI
Dedifferentiation
Compensation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Centre for Advanced Imaging Publications
 
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Created: Wed, 16 Oct 2013, 08:58:54 EST by Anna Cotroneo on behalf of Centre for Advanced Imaging