Restenosis treatments using nanoparticle-based drug delivery systems

Gu, Zi, Rolfe, Barbara E., Thomas, Anita C. and Xu, Zhi Ping (2013) Restenosis treatments using nanoparticle-based drug delivery systems. Current Pharmaceutical Design, 19 35: 6330-6339. doi:10.2174/1381612811319350009

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Author Gu, Zi
Rolfe, Barbara E.
Thomas, Anita C.
Xu, Zhi Ping
Title Restenosis treatments using nanoparticle-based drug delivery systems
Journal name Current Pharmaceutical Design   Check publisher's open access policy
ISSN 1381-6128
Publication date 2013-10
Sub-type Article (original research)
DOI 10.2174/1381612811319350009
Open Access Status File (Author Post-print)
Volume 19
Issue 35
Start page 6330
End page 6339
Total pages 10
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2014
Language eng
Formatted abstract
Restenosis, the re-narrowing of a blood vessel after removal of atherosclerotic plaque, is a major limitation of surgical treatments for atherosclerosis. Various attempts to prevent or treat restenosis by pharmacological or mechanical approaches have had limited success in clinical trials. Hence, there is wide interest in developing new strategies to prevent or treat restenosis. This review discusses ‘a new-generation therapy’ that uses functional nanoparticles to effectively deliver active drug molecules. The potential platforms for nanoparticle-based solutions to restenosis include organic (e.g. polymers, liposomes, and proteins) and inorganic nanoparticles (e.g. layered double hydroxides, titanium oxide nanotubes, and magnetic nanoparticles,). Many in vitro and in vivo studies based on these platforms demonstrate the feasibility and potential of using nanoparticle drug delivery systems for preventing or treating restenosis, but as yet few have reached clinical trials. It is suggested that using inorganic nanoparticles to target deliver multi-functional drugs will be a promising approach to preventing or treating restenosis.
Keyword Restenosis
Drug delivery
Layered double hydroxide
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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Created: Tue, 15 Oct 2013, 15:43:29 EST by Cathy Fouhy on behalf of Functional Nanomaterials