Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter

Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2013) Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Edition), 52 46: 12020-12023. doi:10.1002/anie.201304660

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Author Brust, Andreas
Wang, Ching-I. A.
Daly, Norelle L.
Kennerly, Joe
Sadeghi, Mahsa
Christie, Macdonald J.
Lewis, Richard J.
Mobli, Mehdi
Alewood, Paul F.
Title Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter
Journal name Angewandte Chemie (International Edition)   Check publisher's open access policy
ISSN 1433-7851
1521-3773
Publication date 2013-11-11
Sub-type Article (original research)
DOI 10.1002/anie.201304660
Open Access Status
Volume 52
Issue 46
Start page 12020
End page 12023
Total pages 4
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag
Collection year 2014
Language eng
Formatted abstract
Loopy peptides: Peptide turn mimetics of a clinically relevant norepinephrine reuptake inhibitor were developed employing a high-throughput synthesis approach to generate peptide thioesters, with subsequent cyclization through native chemical ligation. The vicinal disulfide constrained cyclic peptidomimetics (see scheme) show high structural and functional similarity to the parent peptide, though with superior metabolic stability.
Keyword Biological activity
Cyclic peptides
Combinatorial chemistry
Drug discovery
Peptidomimetics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 24 SEP 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
Centre for Advanced Imaging Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Tue, 15 Oct 2013, 12:15:38 EST by Anna Cotroneo on behalf of Institute for Molecular Bioscience