Cell interactions at the nanoscale: piezoelectric stimulation

Curtis, Adam S. G., Reid, Stuart, Martin, Iain, Vaidyanathan, Ramanathan, Smith, Carol-Anne, Nikukar, Habib and Dalby, Matthew J. (2013) Cell interactions at the nanoscale: piezoelectric stimulation. IEEE Transactions On Nanobioscience, 12 3: 247-254. doi:10.1109/TNB.2013.2257837

Author Curtis, Adam S. G.
Reid, Stuart
Martin, Iain
Vaidyanathan, Ramanathan
Smith, Carol-Anne
Nikukar, Habib
Dalby, Matthew J.
Title Cell interactions at the nanoscale: piezoelectric stimulation
Journal name IEEE Transactions On Nanobioscience   Check publisher's open access policy
ISSN 1536-1241
Publication date 2013-09
Year available 2013
Sub-type Article (original research)
DOI 10.1109/TNB.2013.2257837
Open Access Status
Volume 12
Issue 3
Start page 247
End page 254
Total pages 8
Place of publication Piscataway, NJ, United States
Publisher Institute of Electrical and Electronics Engineers
Collection year 2014
Language eng
Abstract Nanometric movements of the substrate on which endothelial cells are growing, driven by periodic sinusoidal vibration from 1 Hz to 50 Hz applied by piezo actuators, upregulate endothelin-1 and Kruppel-like factor 2 expression, and increase cell adhesion. These movements are in the z (vertical) axis and ranges from 5 to 50 nm and are similar in vertical extent to protrusions from the cells themselves already reported in the literature. White noise vibrations do not to produce these effects. Vibrational sweeps, if suitably confined within a narrow frequency range, produce similar stimulatory effects but not at wider sweeps. These effects suggest that coherent vibration is crucial for driving these cellular responses. In addition to this, the applied stimulations are observed to be close to or below the random seismic noise of the surroundings, which may suggest stochastic resonance is being employed. The stimulations also interact with the effects of nanometric patterning of the substrates on cell adhesion and Kruppel-like factor 2 and endothelin-1 expression thus linking cell reactions to nanotopographically patterned surfaces with those to mechanical stimulation.
Keyword Cell adhesion
Endothelial cd 133+ cells
Gene expression
Nanoscale mechanical stimulation
Stochastic resonance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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