Age-specific and sex-specific morbidity and mortality from avian influenza A(H7N9)

Dudley, Joseph P. and Mackay, Ian M. (2013) Age-specific and sex-specific morbidity and mortality from avian influenza A(H7N9). Journal of Clinical Virology, 58 3: 568-570. doi:10.1016/j.jcv.2013.09.004

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Author Dudley, Joseph P.
Mackay, Ian M.
Title Age-specific and sex-specific morbidity and mortality from avian influenza A(H7N9)
Journal name Journal of Clinical Virology   Check publisher's open access policy
ISSN 1386-6532
Publication date 2013-11
Sub-type Article (original research)
DOI 10.1016/j.jcv.2013.09.004
Volume 58
Issue 3
Start page 568
End page 570
Total pages 3
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
We used data on age and sex for 136 laboratory confirmed human A(H7N9) cases reported as of 11 August 2013 to compare age-specific and sex-specific patterns of morbidity and mortality from the avian influenza A(H7N9) virus with those of the avian influenza A(H5N1) virus. Human A(H7N9) cases exhibit high degrees of age and sex bias: mortality is heavily biased toward males >50 years, no deaths have been reported among individuals <25 years old, and relatively few cases documented among children or adolescents. The proportion of fatal cases (PFC) for human A(H7N9) cases as of 11 August 2013 was 32%, compared to a cumulative PFC for A(H5N1) of 83% in Indonesia and 36% in Egypt. Approximately 75% of cases of all A(H7N9) cases occurred among individuals >45 years old. Morbidity and mortality from A(H7N9) are lowest among individuals between 10 and 29 years, the age group which exhibits the highest cumulative morbidity and case fatality rates from A(H5N1). Although individuals <20 years old comprise nearly 50% of all human A(H5N1) cases, only 7% of all reported A(H7N9) cases and no deaths have been reported among individuals in this age group. Only 4% of A(H7N9) cases occurred among children < 5 years old, and only one case from the 10 to 20 year age group. Age- and sex-related differences in morbidity and mortality from emerging zoonotic diseases can provide insights into ecological, economic, and cultural factors that may contribute to the emergence and proliferation of novel zoonotic diseases in human populations.
Keyword Age-specific
Avian influenza
Emerging diseases
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 12 September 2013.

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Created: Fri, 11 Oct 2013, 10:24:46 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences