Natural killer cells in patients with severe chronic fatigue syndrome

Brenu, E. W., Hardcastle, S. L., Atkinson, G. M., van Driel, M. L., Kreijkamp-Kaspers, S., Ashton, K. J., Staines, D. R. and Marshall-Gradisnik, S. M. (2013) Natural killer cells in patients with severe chronic fatigue syndrome. Autoimmunity Highlights, Online First 1-12. doi:10.1007/s13317-013-0051-x

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Author Brenu, E. W.
Hardcastle, S. L.
Atkinson, G. M.
van Driel, M. L.
Kreijkamp-Kaspers, S.
Ashton, K. J.
Staines, D. R.
Marshall-Gradisnik, S. M.
Title Natural killer cells in patients with severe chronic fatigue syndrome
Journal name Autoimmunity Highlights   Check publisher's open access policy
ISSN 2038-0305
Publication date 2013-04-16
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s13317-013-0051-x
Volume Online First
Start page 1
End page 12
Total pages 12
Place of publication Milan, Italy
Publisher Springer Italia
Collection year 2014
Language eng
Formatted abstract
Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS). The purpose of this review is to highlight the different profiles of NK cells reported in CFS patients and to determine the extent of NK immune dysfunction in subtypes of CFS patients based on severity in symptoms.
Keyword Chronic fatigue syndrome
Natural killer cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online 16 April 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
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Created: Wed, 09 Oct 2013, 08:37:40 EST by Shani Lamb on behalf of Discipline of General Practice