PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

Nassar, Zeyad D., Moon, Hyeongsun, Duong, Tam, Neo, LiQi, Hill, Michelle M., Francois, Mathias, Parton, Robert G. and Parat, Marie-Odile (2013) PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis. Oncotarget, Advance Online 1-12.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Author Nassar, Zeyad D.
Moon, Hyeongsun
Duong, Tam
Neo, LiQi
Hill, Michelle M.
Francois, Mathias
Parton, Robert G.
Parat, Marie-Odile
Title PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis
Journal name Oncotarget   Check publisher's open access policy
ISSN 1949-2553
Publication date 2013-10-04
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume Advance Online
Start page 1
End page 12
Total pages 12
Place of publication Albany, NY, United States
Publisher Impact Journals
Collection year 2014
Language eng
Formatted abstract
Caveolae are specialized plasma membrane subdomains implicated in cellular functions such as migration, signalling and trafficking. Caveolin-1 and polymerase I and transcript release factor (PTRF)/cavin-1 are essential for caveola formation. Caveolin-1 is overexpressed and secreted in prostate tumors and promotes aggressiveness and angiogenesis. In contrast, a lack of PTRF expression is reported in prostate cancer, and ectopic PTRF expression in prostate cancer cells inhibits tumor growth and metastasis. We experimentally manipulated PTRF expression in three prostate cancer cell lines, namely the caveolin-1 positive cells PC3 and DU145 and the caveolin-1-negative LNCaP cells, to evaluate angiogenesis- and lymphangiogenesis-regulating functions of PTRF. We show that the conditioned medium of PTRF-expressing prostate cancer cells decreases ECs proliferation, migration and differentiation in vitro and ex vivo. This can occur independently from caveolin-1 expression and secretion or caveola formation, since the anti-angiogenic effects of PTRF were detected in caveolin-1-negative LNCaP cells. Additionally, PTRF expression in PC3 cells significantly decreased blood and lymphatic vessel densities in orthotopic tumors in mice. Our results suggest that the absence of PTRF in prostate cancer cells contributes significantly to tumour progression and metastasis by promoting the angiogenesis and lymphangiogenesis potential of the cancer cells, and this could be exploited for therapy.
Keyword PTRF
Prostate cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published: October 4, 2013

Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 08 Oct 2013, 15:46:07 EST by Myrtle Sahabandu on behalf of School of Pharmacy