Abdominal obesity and Barrett's oesophagus - does hip obesity reduce the risk?

Kendall, B. J., Macdonald, G. A., Prins, J. B., O'Brien, S. and Whiteman, D. C. (2013). Abdominal obesity and Barrett's oesophagus - does hip obesity reduce the risk?. In: Australian Gastroenterology Week 2013, Melbourne Australia, (127-127). 7-9 October 2013. doi:10.1111/jgh.12365_7

Author Kendall, B. J.
Macdonald, G. A.
Prins, J. B.
O'Brien, S.
Whiteman, D. C.
Title of paper Abdominal obesity and Barrett's oesophagus - does hip obesity reduce the risk?
Conference name Australian Gastroenterology Week 2013
Conference location Melbourne Australia
Conference dates 7-9 October 2013
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
Place of Publication Richmond Australia
Publisher Wiley-Blackwell Publishing Asia
Publication Year 2013
Sub-type Published abstract
DOI 10.1111/jgh.12365_7
Open Access Status
ISSN 0815-9319
Volume 28
Issue S2
Start page 127
End page 127
Total pages 1
Language eng
Formatted Abstract/Summary
Background: Abdominal obesity is strongly associated with the risk of Barrett's oesophagus (BO). Hip obesity appears to protect against the cardiovascular and metabolic consequences of abdominal obesity. A recent study in men has suggested hip obesity may similarly be protective against the effects of abdominal obesity on risk of BO

Aim: To conduct a case-control study to assess the effects of hip obesity on the risk of BO associated with abdominal obesity.

Methods: We undertook a structured interview, clinical and anthropometric measures within a case-control study conducted in Brisbane, Australia. We recruited 237 cases (70% Males, Mean age 62.1 yrs) with histologically confirmed BO diagnosed 2003–6 and 247 controls from the electoral roll, frequency matched by age and sex to cases. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression analysis. Sex adjusted tertile cut points in the control population were used for classification of anthropometric variables with the lowest tertile being used as the reference category.

Results: Hip circumference (Cases 106.4 cm, Controls 105.0 cm; p = 0.05) and waist circumference (Cases 101.8 cm, Controls 97.4 cm; p = 0.002) were higher in cases than controls. Both hip circumference (OR 1.76; 1.12–2.76) and waist circumference (OR 2.18; 1.37–3.45) were associated with the risk of BO. When adjusted for each other, the association with waist circumference (OR 2.31; 1.17–4.57) strengthened but the association with hip circumference was abolished (OR 0.94; 0.48–1.84). These effects were greater in men than women, with an inverse association between high hip circumference and risk of BO when adjusted for waist circumference in men (OR 0.57;0.25–1.31, per 5 cm increments OR 0.79; 0.64–0.98).

As with risk of cardiovascular and metabolic disease, the risk of BO associated with abdominal obesity appears to be attenuated by hip obesity, particular in men. The mechanism for this is uncertain but factors including the metabolic “sink” effect of hip obesity warrant further study.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: School of Medicine Publications
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