Associations between particular types of fetal malformation and antiepileptic drug exposure in utero

Vajda, F. J. E., O'Brien, T. J., Graham, J., Lander, C. M. and Eadie, M. J. (2013) Associations between particular types of fetal malformation and antiepileptic drug exposure in utero. Acta Neurologica Scandinavica, 128 4: 228-234. doi:10.1111/ane.12115


Author Vajda, F. J. E.
O'Brien, T. J.
Graham, J.
Lander, C. M.
Eadie, M. J.
Title Associations between particular types of fetal malformation and antiepileptic drug exposure in utero
Formatted title
Associations between particular types of fetal malformation and antiepileptic drug exposure in utero
Journal name Acta Neurologica Scandinavica   Check publisher's open access policy
ISSN 0001-6314
1600-0404
Publication date 2013-10-01
Sub-type Article (original research)
DOI 10.1111/ane.12115
Volume 128
Issue 4
Start page 228
End page 234
Total pages 7
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Collection year 2014
Language eng
Formatted abstract
Objective: To study associations between patterns of fetal malformation and individual antiepileptic drugs taken during pregnancy.

Methods: Multiple variable logistic regression and other statistical analyses of data relating to 1733 fetuses from 1703 pregnancies (147 of which were not exposed to antiepileptic drugs during pregnancy).

Results: There were statistically significant (P < 0.05) associations between (i) valproate exposure and spina bifida, malformations of the heart and great vessels, digits, skull bones, and brain, but not hypospadias, cleft palate/lip and mouth abnormalities, (ii) topiramate exposure and hypospadias and brain maldevelopments, and (iii) carbamazepine (CBZ) exposure and renal tract abnormalities.

Conclusions: The valproate findings are mostly in keeping with the published literature, but the topiramate finding regarding hypospadias and the association between CBZ exposure and various renal tract abnormalities raise questions of organ specific teratogenesis. More extensive data are desirable, particularly in relation to topiramate, which is being used increasingly as a migraine prophylactic in women of childbearing potential.
Keyword Antiepileptic drugs
Hypospadias
Malformations
Pregnancy
Topiramate
Valproate
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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