Insecticidal bed nets and filariasis transmission in Papua New Guinea

Reimer, Lisa J., Thomsen, Edward K., Tisch, Daniel J., Henry-Halldin, Cara N., Zimmerman, Peter A., Baea, Manasseh E., Dagoro, Henry, Susapu, Melinda, Hetzel, Manuel W., Bockarie, Moses J., Michael, Edwin, Siba, Peter M. and Kazura, James W. (2013) Insecticidal bed nets and filariasis transmission in Papua New Guinea. New England Journal of Medicine, 369 8: 745-753. doi:10.1056/NEJMoa1207594

Author Reimer, Lisa J.
Thomsen, Edward K.
Tisch, Daniel J.
Henry-Halldin, Cara N.
Zimmerman, Peter A.
Baea, Manasseh E.
Dagoro, Henry
Susapu, Melinda
Hetzel, Manuel W.
Bockarie, Moses J.
Michael, Edwin
Siba, Peter M.
Kazura, James W.
Title Insecticidal bed nets and filariasis transmission in Papua New Guinea
Journal name New England Journal of Medicine   Check publisher's open access policy
ISSN 0028-4793
Publication date 2013-08
Year available 2013
Sub-type Article (original research)
DOI 10.1056/NEJMoa1207594
Open Access Status
Volume 369
Issue 8
Start page 745
End page 753
Total pages 9
Place of publication Boston, United States
Publisher Massachusetts Medical Society
Collection year 2014
Language eng
Formatted abstract
Global efforts to eliminate lymphatic filariasis are based on the annual mass administration of antifilarial drugs to reduce the microfilaria reservoir available to the mosquito vector. Insecticide-treated bed nets are being widely used in areas in which filariasis and malaria are coendemic.

We studied five villages in which five annual mass administrations of antifilarial drugs, which were completed in 1998, reduced the transmission of Wuchereria bancrofti, one of the nematodes that cause lymphatic filariasis. A total of 21,899 anopheles mosquitoes were collected for 26 months before and 11 to 36 months after bed nets treated with long-lasting insecticide were distributed in 2009. We evaluated the status of filarial infection and the presence of W. bancrofti DNA in anopheline mosquitoes before and after the introduction of insecticide-treated bed nets. We then used a model of population dynamics to estimate the probabilities of transmission cessation.

Village-specific rates of bites from anopheline mosquitoes ranged from 6.4 to 61.3 bites per person per day before the bed-net distribution and from 1.1 to 9.4 bites for 11 months after distribution (P<0.001). During the same period, the rate of detection of W. bancrofti in anopheline mosquitoes decreased from 1.8% to 0.4% (P=0.005), and the rate of detection of filarial DNA decreased from 19.4% to 14.9% (P=0.13). The annual transmission potential was 5 to 325 infective larvae inoculated per person per year before the bed-net distribution and 0 after the distribution. Among all five villages with a prevalence of microfilariae of 2 to 38%, the probability of transmission cessation increased from less than 1.0% before the bed-net distribution to a range of 4.9 to 95% in the 11 months after distribution.

Vector control with insecticide-treated bed nets is a valuable tool for W. bancrofti elimination in areas in which anopheline mosquitoes transmit the parasite. (Funded by the U.S. Public Health Service and the National Institutes of Health.)
Keyword Eliminate lymphatic filariasis
Wuchereria bancrofti infection
Vector control
Global program
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 28 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 06 Oct 2013, 00:05:19 EST by System User on behalf of School of Public Health