The role of genes in the insomnia phenotype

Gehrman, Philip R., Pfeiffenberger, Cory and Byrne, Enda M. (2013) The role of genes in the insomnia phenotype. Sleep Medicine Clinics, 8 3: 323-331. doi:10.1016/j.jsmc.2013.04.005

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Author Gehrman, Philip R.
Pfeiffenberger, Cory
Byrne, Enda M.
Title The role of genes in the insomnia phenotype
Journal name Sleep Medicine Clinics   Check publisher's open access policy
ISSN 1556-407X
1556-4088
Publication date 2013-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jsmc.2013.04.005
Volume 8
Issue 3
Start page 323
End page 331
Total pages 9
Editor Jack D. Edinger
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders Co.
Collection year 2014
Language eng
Formatted abstract
Key points
• With the development of genetic model systems for sleep, it seems logical to use them to screen human insomnia genetic studies for bona fide hits and to further characterize the mechanisms behind insomnia.
• Studies on the genetics of insomnia must be an important component of future research on the disorder.
• Understanding of the role of genes in the insomnia phenotype is limited.
• There are several molecular genetic tools available that were not in existence even a few years ago.
• The time is ripe for research on the genetics of insomnia that may finally shed light on the mechanisms of this common sleep disorder.

Current conceptualizations of insomnia are largely based on the 3 Ps (Predisposing, Precipitating, and Perpetuating factors) model in its original or adapted form. According to this model, the onset of acute insomnia is due to the interaction between 1 or more precipitating factors and premorbid predisposing factors. Predisposing factors can increase vulnerability to developing insomnia or, when low, may confer a degree of resiliency. There is no universally agreed-on set of predisposing factors, but virtually all presentations of the model suggest that genetic factors may play a role. Yet, there has been little research in the genetic basis of insomnia. This is beginning to change, and investigations are starting to take advantage of the powerful tools that are part of the genomics revolution currently under way. The goal of this article is to summarize current understanding of the role of genetics in the pathophysiology of insomnia.
Keyword Insomnia
Genetics
GWAS
Animal models
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Queensland Brain Institute Publications
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Created: Thu, 03 Oct 2013, 11:41:54 EST by Debra McMurtrie on behalf of Queensland Brain Institute