Aging in the nervous system of Caenorhabditis elegans

Chew, Yee Lian, Fan, Xiaochen, Goetz, Juergen and Nicholas, Hannah R. (2013) Aging in the nervous system of Caenorhabditis elegans. Communicative and Integrative Biology, 6 5: e25288.1-e25288.6. doi:10.4161/cib.25288


Author Chew, Yee Lian
Fan, Xiaochen
Goetz, Juergen
Nicholas, Hannah R.
Title Aging in the nervous system of Caenorhabditis elegans
Formatted title
Aging in the nervous system of Caenorhabditis elegans
Journal name Communicative and Integrative Biology   Check publisher's open access policy
ISSN 1942-0889
Publication date 2013-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4161/cib.25288
Open Access Status DOI
Volume 6
Issue 5
Start page e25288.1
End page e25288.6
Total pages 6
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Collection year 2014
Language eng
Formatted abstract
It has recently been described that aging in C. elegans is accompanied by the progressive development of morphological changes in the nervous system. These include novel outgrowths from the cell body or axonal process, as well as blebbing and beading along the length of the axon. The formation of these structures is regulated by numerous molecular players including members of the well-conserved insulin/insulin growth factor-like (IGF)-1 signaling and mitogen-activated protein (MAP) kinase pathways. This review summarizes the recent literature on neuronal aging in C. elegans, including our own findings, which indicate a role for protein with tau-like repeats (PTL-1), the homolog of mammalian tau and MAP2/4, in maintaining neuronal integrity during aging.
Keyword Caenorhabditis elegans
Aging
Lifespan
Neuronal aging
Protein with tau-like repeats
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Queensland Brain Institute Publications
 
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Created: Wed, 02 Oct 2013, 12:20:25 EST by Debra McMurtrie on behalf of Queensland Brain Institute