Ventilation induced apnea and its effect on dorsal brainstem inspiratory neurones in the rat

Subramanian, Hari H., Balnave, Ron J. and Chow, Chin M. (2007) Ventilation induced apnea and its effect on dorsal brainstem inspiratory neurones in the rat. Respiratory Physiology and Neurobiology, 157 2-3: 252-261. doi:10.1016/j.resp.2007.02.010


Author Subramanian, Hari H.
Balnave, Ron J.
Chow, Chin M.
Title Ventilation induced apnea and its effect on dorsal brainstem inspiratory neurones in the rat
Journal name Respiratory Physiology and Neurobiology   Check publisher's open access policy
ISSN 1569-9048
1878-1519
Publication date 2007-08
Sub-type Article (original research)
DOI 10.1016/j.resp.2007.02.010
Volume 157
Issue 2-3
Start page 252
End page 261
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The purpose of this study was to examine the effect of mechanical ventilation (MV) on inherent breathing and on dorsal brainstem nucleus tractus solitarius (NTS) respiratory cell function. In pentobarbitone-anaesthetised rats, application of MV at combined high frequencies and volumes (representing threshold levels) produced apnea. The apnea persisted as long as MV was maintained at or above the threshold frequency and volume. Following removal of MV, inherent breathing did not resume immediately, with the diaphragm exhibiting post-mechanical ventilation apnea. The fall in arterial P C O2 (P a C O2) levels evoked by MV-engendered hyperventilation was shown not to be the trigger for initiation of apnea. MV-induced apnea was immediately reversed by bilateral vagotomy. Further, MV-induced apnea could not be evoked in bilaterally vagotomized animals suggesting that vagal feedback is the critical pathway for its initiation. NTS inspiratory neurones were inhibited during both MV-induced apnea and post-mechanical ventilation apnea, implying the involvement of central neural mechanisms in mediating this effect.
Keyword Mechanical apneic thresholds
Vagal memory
NTS inspiratory neurones
Post-mechanical ventilation apnea
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Queensland Brain Institute Publications
 
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Created: Tue, 01 Oct 2013, 14:51:58 EST by Hari Subramanian on behalf of UQ Centre for Clinical Research