The Midbrain Periaqueductal Gray Control of Respiration

Subramanian, Hari H., Balnave, Ron J. and Holstege, Gert (2008) The Midbrain Periaqueductal Gray Control of Respiration. Journal of Neuroscience, 28 47: 12274-12283. doi:10.1523/JNEUROSCI.4168-08.2008

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Author Subramanian, Hari H.
Balnave, Ron J.
Holstege, Gert
Title The Midbrain Periaqueductal Gray Control of Respiration
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2008-11
Year available 2008
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4168-08.2008
Open Access Status File (Publisher version)
Volume 28
Issue 47
Start page 12274
End page 12283
Total pages 10
Place of publication Washington, DC United States
Publisher Society for Neuroscience
Collection year 2009
Language eng
Formatted abstract
The midbrain periaqueductal gray (PAG) organizes basic survival behavior, which includes respiration. How the PAG controls respiration is not known. We studied the PAG control of respiration by injecting D,L-homocysteic acid in the PAG in unanesthetized precollicularly decerebrated cats. Injections in different parts of the PAG caused different respiratory effects. Stimulation in the dorsomedial PAG induced slow and deep breathing and dyspnea. Stimulation in the dorsolateral PAG resulted in active breathing and tachypnea consistent with the respiratory changes during fright and flight. Stimulation in the medial part of lateral PAG caused inspiratory apneusis. Stimulation in lateral parts of the lateral and ventrolateral PAG produced respiratory changes associated with vocalization (mews, alternating mews and hisses, or hisses). D,L-Homocysteic acid injections in the caudal ventrolateral PAG induced irregular breathing. These results demonstrate that the PAG exerts a strong influence on respiration, suggesting that it serves as the behavioral modulator of breathing.
Keyword Midbrain
Emotional breathing control
Pattern generation
Periaqueductal Gray
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes This publication has been cited by Faculty 1000 Biology

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 64 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 71 times in Scopus Article | Citations
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Created: Tue, 01 Oct 2013, 14:11:04 EST by Hari Subramanian on behalf of UQ Centre for Clinical Research