FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study

Wang, David K., Varanasi, Srinivas, Fredericks, Peter M., Hill, David J. T., Symons, Anne L., Whittaker, Andrew K. and Rasoul, Firas (2013) FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study. Journal of Polymer Science Part A: Polymer Chemistry, 51 24: 5163-5176. doi:10.1002/pola.26930

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Author Wang, David K.
Varanasi, Srinivas
Fredericks, Peter M.
Hill, David J. T.
Symons, Anne L.
Whittaker, Andrew K.
Rasoul, Firas
Title FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study
Journal name Journal of Polymer Science Part A: Polymer Chemistry   Check publisher's open access policy
ISSN 0887-624X
1099-0518
Publication date 2013-12-15
Year available 2013
Sub-type Article (original research)
DOI 10.1002/pola.26930
Open Access Status File (Author Post-print)
Volume 51
Issue 24
Start page 5163
End page 5176
Total pages 14
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2014
Language eng
Formatted abstract
A series of the biodegradable copolyester hydrogels was prepared using a redox-initiated polymerization with a constant 1:9 mole ratio of the Boltorn-based acrylate and diacrylate triblock comacromonomers. The Boltorn® macromonomer was derived from the hyperbranched polyester Boltorn H20, which was functionalized at each terminus with poly(ethylene glycol) acrylate, and the diacrylate triblock macromonomer was poly (lactide-b-ethylene glycol-b-lactide) diacrylate. The hydrolysis of the copolyesters at pH 7.4 in a phosphate buffered saline solution at 37 °C was studied using ATR-FTIR spectroscopy. It was found that the presence of the Boltorn, the PEG, and lactide block lengths both play vital roles in determining the structure-property relationships in these materials. The ATR-FTIR studies showed that with increasing lactide segment length, the rate of ester hydrolysis increased due to the increased concentration of the hydrolytically sensitive poly(lactic acid) (PLA) ester groups in the network. However, incorporation of Boltorn into the PLA-PEG-PLA copolymer did not significantly change the kinetic rate constant for hydrolysis of the PLA segments. The cytocompatibility of a typical one of these materials in the presence of its degradation by-products was assessed using cultured osteoblasts from the rat. The hydrogel was degraded for 28 days and found to be cytocompatible with osteoblasts over days 23 to 28 of the hydrolysis period.
Keyword Biocompatibility
Degradation
FT-IR
Hydrolytic degradation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 30 Sep 2013, 23:09:50 EST by Mrs Louise Nimwegen on behalf of Aust Institute for Bioengineering & Nanotechnology