In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites

Andriani, Yosephine, Morrow, Isabel C., Taran, Elena, Edwards, Grant A., Schiller, Tara L., Osman, Azlin F. and Martin, Darren J. (2013) In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites. Acta Biomaterialia, 9 9: 8308-8317. doi:10.1016/j.actbio.2013.05.021


Author Andriani, Yosephine
Morrow, Isabel C.
Taran, Elena
Edwards, Grant A.
Schiller, Tara L.
Osman, Azlin F.
Martin, Darren J.
Title In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites
Journal name Acta Biomaterialia   Check publisher's open access policy
ISSN 1742-7061
1878-7568
Publication date 2013-09
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.actbio.2013.05.021
Volume 9
Issue 9
Start page 8308
End page 8317
Total pages 10
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
We have prepared a number of silicone-based thermoplastic polyurethane (TPU) nanocomposites and demonstrated an enhancement of in vitro biostability against metal-ion-induced oxidation for potential use in long-term implantable medical devices. Organoclays based on both low-aspect-ratio hectorites and high-aspect-ratio fluoromicas were evaluated after being dual-modified with two quaternary alkyl ammonium salts with differing degrees of polarity. The resultant nanocomposites were tested for in vitro biostability using physiologically relevant oxidizing conditions. Subsequently, the effects of oxidative treatment on the surface degradation and bulk mechanical integrity of the nanocomposites were investigated and compared with the parent TPUs to identify nanocomposites with the most desirable features for long-term implantation. Here, we demonstrate that the low-aspect-ratio organohectorite was delaminated and well dispersed in the nanocomposites. Importantly, these factors gave rise to the enhanced oxidative stability. In addition, the mechanical properties of all nanocomposites were less adversely affected by the oxidative treatment compared to their parent TPUs. These results suggest the potential for improved mechanical integrity and biostability when suitable dual modified organoclays are incorporated in a silicone-based TPU.
Keyword Polyurethane
Organoclay
Nanocomposite
Biostability
Biomaterial
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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