Changes in Body Fat Distribution and Fitness Are Associated With Changes in Hemoglobin A(1c) After 9 Months of Exercise Training: Results from the HART-D study

Senechal, Martin, Swift, Damon L., Johannsen, Neil M., Blair, Steven N., Earnest, Conrad P., Lavie, Carl J. and Church, Timothy S. (2013) Changes in Body Fat Distribution and Fitness Are Associated With Changes in Hemoglobin A(1c) After 9 Months of Exercise Training: Results from the HART-D study. Diabetes Care, 36 9: 2843-2849. doi:10.2337/dc12-2428

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Author Senechal, Martin
Swift, Damon L.
Johannsen, Neil M.
Blair, Steven N.
Earnest, Conrad P.
Lavie, Carl J.
Church, Timothy S.
Title Changes in Body Fat Distribution and Fitness Are Associated With Changes in Hemoglobin A(1c) After 9 Months of Exercise Training: Results from the HART-D study
Formatted title
Changes in Body Fat Distribution and Fitness Are Associated With Changes in Hemoglobin A1c After 9 Months of Exercise Training: Results from the HART-D study
Journal name Diabetes Care   Check publisher's open access policy
ISSN 0149-5992
1935-5548
Publication date 2013-09-01
Year available 2013
Sub-type Article (original research)
DOI 10.2337/dc12-2428
Volume 36
Issue 9
Start page 2843
End page 2849
Total pages 7
Place of publication Alexandria, United States
Publisher American Diabetes Association
Collection year 2014
Language eng
Formatted abstract
OBJECTIVE To investigate the associations between changes in body composition and fitness after exercise training and changes in hemoglobin A1c (HbA1c) in individuals with type 2 diabetes.

RESEARCH DESIGN AND METHODS Participants (n = 201) were randomized to aerobic, resistance, or combined training for 9 months. HbA1c, waist circumference, total and trunk fat mass, appendicular fat mass, lean body mass, isokinetic leg muscle strength, peak O2 uptake, and estimated METs were assessed at baseline and follow-up. Change in HbA1c was evaluated across quartiles of change in body composition and fitness.

RESULTS Change in HbA1c was associated with changes in body weight (r = 0.13, P = 0.052), waist circumference (r = 0.17, P = 0.013), trunk fat mass (r = 0.19, P = 0.005), and estimated METs (r = −0.16, P = 0.023). There was a trend in change in HbA1c across quartiles of waist circumference (P = 0.011), trunk fat mass (P = 0.020), and estimated METs (P = 0.011). Participants with increased estimated METs and reduced trunk fat mass had greater odds of having reduced HbA1c after training (3.48, 1.46–8.31). Finally, participants with increased estimated METs and reduced waist circumference were 2.81 (1.13–6.98) times more likely to have reduced HbA1c and type 2 diabetes medication use than those without improved fitness and central adiposity.

CONCLUSIONS In patients with type 2 diabetes, a reduction in central adiposity and increase in fitness were the most prominent predictors of the change in HbA1c in response to exercise training.
Keyword Randomized Controlled-Trial
Improves Insulin Sensitivity
Type-2 Diabetic Men
Glycemic Control
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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