Protective effects of selenium on oxidative damage and oxidative stress related gene expression in rat liver under chronic poisoning of arsenic

Xu Zhao, Wang Zhou, Li Jian-jun, Chen Chen, Zhang Ping-chuan, Dong Lu, Chen Jing-hong, Chen Qun, Zhang Xiao-tian and Wang Zhi-lun (2013) Protective effects of selenium on oxidative damage and oxidative stress related gene expression in rat liver under chronic poisoning of arsenic. Food and Chemical Toxicology, 58 1-7. doi:10.1016/j.fct.2013.03.048

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Author Xu Zhao
Wang Zhou
Li Jian-jun
Chen Chen
Zhang Ping-chuan
Dong Lu
Chen Jing-hong
Chen Qun
Zhang Xiao-tian
Wang Zhi-lun
Title Protective effects of selenium on oxidative damage and oxidative stress related gene expression in rat liver under chronic poisoning of arsenic
Journal name Food and Chemical Toxicology   Check publisher's open access policy
ISSN 0278-6915
1873-6351
Publication date 2013-08
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.fct.2013.03.048
Open Access Status File (Author Post-print)
Volume 58
Start page 1
End page 7
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2014
Language eng
Formatted abstract
Arsenic (As) is a toxic metalloid existing widely in the environment, and chronic exposure to it through contaminated drinking water has become a global problem of public health. The present study focused on the protective effects of selenium on oxidative damage of chronic arsenic poisoning in rat liver. Rats were divided into four groups at random and given designed treatments for 20 weeks. The oxidative damage of liver tissue was evaluated by lipid peroxidation and antioxidant enzymes. Oxidative stress related genes were detected to reflect the liver stress state at the molecular level. Compared to the control and Na2SeO3 groups, the MDA content in liver tissue was decreased and the activities of antioxidant enzymes were increased in the Na2SeO3 intervention group. The mRNA levels of SOD1, CAT, GPx and Txnrd1 were increased significantly (P < 0.05) in the combined Na2SeO3 + NaAsO2 treatment group. The expressions of HSP70 and HO-1 were significantly (P < 0.05) increased in the NaAsO2 group and reduced in the combined treatment group. The results indicate that long-term intake of NaAsO2 causes oxidative damage in the rat liver, and Na2SeO3 protects liver cells by adjusting the expression of oxidative stress related genes to improve the activities of antioxidant enzymes.
Keyword Na2SeO3
NaAsO2
Liver
Oxidative stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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