Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) report

Manchia, Mirko, Adli, Mazda, Akula, Nirmala, Ardau, Raffaella, Aubry, Jean-Michel, Backlund, Lena, Banzato, Claudio E. M., Baune, Bernhard T., Bellivier, Frank, Bengesser, Susanne, Biernacka, Joanna M., Brichant-Petitjean, Clara, Bui, Elise, Calkin, Cynthia V., Cheng, Andrew Tai Ann, Chillotti, Caterina, Cichon, Sven, Clark, Scott, Czerski, Piotr M., Dantas, Clarissa, Del Zompo, Maria, DePaulo, J. Raymond, Detera-Wadleigh, Sevilla D., Etain, Bruno, Falkai, Peter, Frisen, Louise, Frye, Mark A., Fullerton, Jan, Gard, Sebastien, Garnham, Julie, Goes, Fernando S., Grof, Paul, Gruber, Oliver, Hashimoto, Ryota, Hauser, Joanna, Heilbronner, Urs, Hoban, Rebecca, Hou, Liping, Jamain, Stephane, Kahn, Jean-Pierre, Kassem, Layla, Kato, Tadafumi, Kelsoe, John R., Kittel-Schneider, Sarah, Kliwicki, Sebastian, Kuo, Po-Hsiu, Kusumi, Ichiro, Laje, Gonzalo, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Lopez Jaramillo, Carlos A., Maj, Mario, Malafosse, Alain, Martinsson, Lina, Masui, Takuya, Mitchell, Philip B., Mondimore, Frank, Monteleone, Palmiero, Nallet, Audrey, Neuner, Maria, Novak, Tomas, O'Donovan, Claire, Osby, Urban, Ozaki, Norio, Perlis, Roy H., Pfennig, Andrea, Potash, James B., Reich-Erkelenz, Daniela, Reif, Andreas, Reininghaus, Eva, Richardson, Sara, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schubert, Oliver K., Schweizer, Barbara, Seemueller, Florian, Grigoroiu-Serbanescu, Maria, Severino, Giovanni, Seymour, Lisa R., Slaney, Claire, Smoller, Jordan W., Squassina, Alessio, Stamm, Thomas, Steele, Jo, Stopkova, Pavla, Tighe, Sarah K., Tortorella, Alfonso, Turecki, Gustavo, Wray, Naomi R., Wright, Adam, Zandi, Peter P., Zilles, David, Bauer, Michael, Rietschel, Marcella, McMahon, Francis J., Schulze, Thomas G. and Alda, Martin (2013) Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) report. PLoS One, 8 6: e65636.1-e65636.9. doi:10.1371/journal.pone.0065636

Author Manchia, Mirko
Adli, Mazda
Akula, Nirmala
Ardau, Raffaella
Aubry, Jean-Michel
Backlund, Lena
Banzato, Claudio E. M.
Baune, Bernhard T.
Bellivier, Frank
Bengesser, Susanne
Biernacka, Joanna M.
Brichant-Petitjean, Clara
Bui, Elise
Calkin, Cynthia V.
Cheng, Andrew Tai Ann
Chillotti, Caterina
Cichon, Sven
Clark, Scott
Czerski, Piotr M.
Dantas, Clarissa
Del Zompo, Maria
DePaulo, J. Raymond
Detera-Wadleigh, Sevilla D.
Etain, Bruno
Falkai, Peter
Frisen, Louise
Frye, Mark A.
Fullerton, Jan
Gard, Sebastien
Garnham, Julie
Goes, Fernando S.
Grof, Paul
Gruber, Oliver
Hashimoto, Ryota
Hauser, Joanna
Heilbronner, Urs
Hoban, Rebecca
Hou, Liping
Jamain, Stephane
Kahn, Jean-Pierre
Kassem, Layla
Kato, Tadafumi
Kelsoe, John R.
Kittel-Schneider, Sarah
Kliwicki, Sebastian
Kuo, Po-Hsiu
Kusumi, Ichiro
Laje, Gonzalo
Lavebratt, Catharina
Leboyer, Marion
Leckband, Susan G.
Lopez Jaramillo, Carlos A.
Maj, Mario
Malafosse, Alain
Martinsson, Lina
Masui, Takuya
Mitchell, Philip B.
Mondimore, Frank
Monteleone, Palmiero
Nallet, Audrey
Neuner, Maria
Novak, Tomas
O'Donovan, Claire
Osby, Urban
Ozaki, Norio
Perlis, Roy H.
Pfennig, Andrea
Potash, James B.
Reich-Erkelenz, Daniela
Reif, Andreas
Reininghaus, Eva
Richardson, Sara
Rouleau, Guy A.
Rybakowski, Janusz K.
Schalling, Martin
Schofield, Peter R.
Schubert, Oliver K.
Schweizer, Barbara
Seemueller, Florian
Grigoroiu-Serbanescu, Maria
Severino, Giovanni
Seymour, Lisa R.
Slaney, Claire
Smoller, Jordan W.
Squassina, Alessio
Stamm, Thomas
Steele, Jo
Stopkova, Pavla
Tighe, Sarah K.
Tortorella, Alfonso
Turecki, Gustavo
Wray, Naomi R.
Wright, Adam
Zandi, Peter P.
Zilles, David
Bauer, Michael
Rietschel, Marcella
McMahon, Francis J.
Schulze, Thomas G.
Alda, Martin
Title Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) report
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-06
Sub-type Article (original research)
DOI 10.1371/journal.pone.0065636
Open Access Status DOI
Volume 8
Issue 6
Start page e65636.1
End page e65636.9
Total pages 9
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2014
Language eng
Formatted abstract
Objective: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen) study.

Materials and Methods: Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling.

Results: Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders).

Conclusions: We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 27 times in Scopus Article | Citations
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