Application of microfluidics to study stem cell dynamics

Chen, Huaying and Nordon, Robert E. (2013). Application of microfluidics to study stem cell dynamics. In Michael K. Danquah and Ram I. Mahato (Ed.), Emerging Trends in Cell and Gene Therapy (pp. 435-470) New York, NY, United States: Springer New York. doi:10.1007/978-1-62703-417-3

Author Chen, Huaying
Nordon, Robert E.
Title of chapter Application of microfluidics to study stem cell dynamics
Title of book Emerging Trends in Cell and Gene Therapy
Place of Publication New York, NY, United States
Publisher Springer New York
Publication Year 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/978-1-62703-417-3
ISBN 978-1-62703-416-6
Editor Michael K. Danquah
Ram I. Mahato
Chapter number 19
Start page 435
End page 470
Total pages 36
Total chapters 26
Collection year 2014
Language eng
Formatted Abstract/Summary
Stem cell fate is directed by a complex chemical and mechanical microenvironment composed of secreted factors, extracellular matrix, and direct interactions with other cells. These signals ultimately control stem cell renewal and lineage fate in a developmental context. It may be possible to dissect the role of specific signaling pathways by precise control of microenvironment. However, traditional flask cell culture methods are unable to control microenvironment at microscale. Microfluidic platforms have the potential of mimicking the signals that direct stem cell fate by precise control of the chemical and mechanical milieu of cells at microscale. Furthermore, so called “lab-on-a-chip” technologies can increase research throughput by cost-effect automation of multiple parallel microscale cultures. This chapter will reveal how microfluidics and lab-on-a-chip technologies can be applied to the study of stem cell dynamics.
Keyword Stem cell dynamics
Micro fluidics
Computational fluid dynamics
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

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Created: Wed, 18 Sep 2013, 10:35:27 EST by Cathy Fouhy on behalf of Aust Institute for Bioengineering & Nanotechnology