Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens

Gauci, Charles G., Jayashi, Cesar M., Gonzalez, Armando E., Lackenby, Julia and Lightowlers, Marshall W. (2012) Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens. Vaccine, 30 26: 3824-3828. doi:10.1016/j.vaccine.2012.04.019


Author Gauci, Charles G.
Jayashi, Cesar M.
Gonzalez, Armando E.
Lackenby, Julia
Lightowlers, Marshall W.
Title Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens
Formatted title
Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
1873-2518
Publication date 2012-06-01
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2012.04.019
Volume 30
Issue 26
Start page 3824
End page 3828
Total pages 5
Place of publication Camden, London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Recombinant antigens from the oncosphere stage of the parasite Taenia solium were expressed in
Escherichia coli. The TSOL16, TSOL45-1A and TSOL45-1B recombinant antigens, each consisting of
fibronectin type III (FnIII) domain S, were produced as fusion proteins with glutathione S-transferase
(GST) and maltose binding protein (MBP). Groups of pigs were immunized twice with the GST fusions
of the antigens and boosted a third time with the MBP fusions prior to receiving a challenge infection
with T. solium eggs. The TSOL16 antigen was found to be capable of inducing high levels of immunity
in pigs against a challenge infection with T. solium. Immunological investigations identified differences
in immune responses in the pigs vaccinated with the various antigens. The results demonstrate that the
TSOL16 antigen could be a valuable adjunct to current porcine vaccination approaches and may allow
the further development of new vaccination strategies against T. solium cysticercosis.
Keyword Recombinant
Vaccine
Antigen
Parasite
Taenia
Cysticercosis
Oncosphere antigens
Antibody-responses
Epitope specificities
Escherichia-Coli
Ovis
Protein
Tsol18
Vaccination
Vaccines
Saginata
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 17 Sep 2013, 21:39:23 EST by Cesar Jayashi Flores on behalf of Aust Institute for Bioengineering & Nanotechnology