Vaccine development against the taenia solium parasite: The role of recombinant protein expression in Escherichia coli

Gauci, Charles G., Jayashi, Cesar M. and Lightowlers, Marshall W. (2013) Vaccine development against the taenia solium parasite: The role of recombinant protein expression in Escherichia coli. Bioengineered, 4 5: 343-347. doi:10.4161/bioe.23003

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Author Gauci, Charles G.
Jayashi, Cesar M.
Lightowlers, Marshall W.
Title Vaccine development against the taenia solium parasite: The role of recombinant protein expression in Escherichia coli
Journal name Bioengineered   Check publisher's open access policy
ISSN 1949-1026
Publication date 2013-09
Year available 2012
Sub-type Article (original research)
DOI 10.4161/bioe.23003
Open Access Status
Volume 4
Issue 5
Start page 343
End page 347
Total pages 5
Place of publication Austin, United States
Publisher Landes Bioscience
Collection year 2014
Language eng
Formatted abstract
Taenia solium is a zoonotic parasite that causes cysticercosis. The parasite is a major cause of human disease in impoverished communities where it is transmitted to humans from pigs which act as intermediate hosts. Vaccination of pigs to prevent transmission of T. solium to humans is an approach that has been investigated to control the disease. A recombinant vaccine antigen, TSOL18, has been remarkably successful at reducing infection of pigs with T. solium in several experimental challenge trials. The vaccine has been shown to eliminate transmission of naturally acquired T. solium in a field trial conducted in Africa. We recently reported that the vaccine was also effective in a field trial conducted in Peru. The TSOL18 recombinant antigen for each of these trials has been produced by expression in Escherichia coli. Here we discuss research that has been undertaken on the TSOL18 antigen and related antigens with a focus on improved methods of preparation of recombinant TSOL18 and optimized expression in Escherichia coli
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published September-October 2013. Published online 29 November 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
ERA White List Items
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 17 Sep 2013, 11:36:51 EST by Cesar Jayashi Flores on behalf of Aust Institute for Bioengineering & Nanotechnology