Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine

Jayashi, Cesar M., Kyngdon, Craig T., Gauci, Charles G., Gonzalez, Armando E. and Lightowlers, Marshall W. (2012) Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine. Veterinary Parasitology, 188 3-4: 261-267. doi:10.1016/j.vetpar.2012.03.055


Author Jayashi, Cesar M.
Kyngdon, Craig T.
Gauci, Charles G.
Gonzalez, Armando E.
Lightowlers, Marshall W.
Title Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine
Journal name Veterinary Parasitology   Check publisher's open access policy
ISSN 0304-4017
1873-2550
Publication date 2012-09-10
Sub-type Article (original research)
DOI 10.1016/j.vetpar.2012.03.055
Volume 188
Issue 3-4
Start page 261
End page 267
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Taenia solium causes cysticercosis in pigs and taeniasis and neurocysticercosis in humans. Oncosphere antigens have proven to be effective as vaccines to protect pigs against an experimental infection with T. solium. A pair-matched vaccination trial field, using a combination of two recombinant antigens, TSOL16 and TSOL18, was undertaken in rural villages of Peru to evaluate the efficacy of this vaccine under natural conditions. Pairs of pigs (n = 137) comprising one vaccinated and one control animal, were allocated to local villagers. Animals received two vaccinations with 200 μg of each of TSOL16 and TSOL18, plus 5 mg Quil-A. Necropsies were performed 7 months after the animals were distributed to the farmers. Vaccination reduced 99.7% and 99.9% (p < 0.01) the total number of cysts and the number of viable cysts, respectively. Immunization with the TSOL16–TSOL18 vaccines has the potential to control T. solium transmission in areas where the disease is endemic, reducing the source for tapeworm infections in humans.
Keyword Neurocysticercosis
Cysticercosis
Taeniasis
TSOL16
TSOL18
Vaccine
Immunization
Pigs
Field trial
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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