Is birth weight a risk factor for ischemic heart disease in later life?

Huxley, Rachel, Owen, Christopher G., Whincup, Peter H., Cook, Derek G., Rich-Edwards, Janet, Smith, George Davey and Collins, Rory (2007) Is birth weight a risk factor for ischemic heart disease in later life?. American Journal of Clinical Nutrition, 85 5: 1244-1250.

Author Huxley, Rachel
Owen, Christopher G.
Whincup, Peter H.
Cook, Derek G.
Rich-Edwards, Janet
Smith, George Davey
Collins, Rory
Title Is birth weight a risk factor for ischemic heart disease in later life?
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0002-9165
Publication date 2007-05
Year available 2007
Sub-type Article (original research)
Volume 85
Issue 5
Start page 1244
End page 1250
Total pages 7
Place of publication Bethesda, MD United States
Publisher American Society for Nutrition
Collection year 2008
Language eng
Formatted abstract
Background:Aninverseassociationbetweenbirthweightandischemic heart disease (IHD) has been seen in observational studies. Objective: We wanted to determine the strength and consistency of the association between birth weight and subsequent IHD. Design:Weconducted a systematic review of observational studies.

Seventeen published studies of birth weight and subsequentIHDwere identified that included a total of 144 794 singletons. Relative risk estimates for the association between birth weight and IHD were available from 16 of these studies. Additional data from 2 unpublished studies of 3801 persons were also included. In total, the analyses included data from 18 studies on 4210 nonfatal and 3308 fatalIHDevents in 147 009 persons. The mean weighted estimate for the association between birth weight and the combined outcome of nonfatal and fatal IHD was 0.84 (95% CI: 0.81, 0.88) per kilogram of birth weight (P < 0.0001). No significant heterogeneity was observed between estimates in different studies (P = 0.09), nor was there evidence of publication bias (P = 0.3, Begg test). Neither restricting the analysis to fatal IHD events nor adjusting for socioeconomic status had any appreciable effect on the findings.

: These findings are consistent with a 1 kg higher birth weight being associated with a 10-20% lower risk of subsequent IHD. However, even if causal, interventions to increase birth weight are unlikely to reduce the incidence of IHD materially. Further studies are needed to determine whether the observed association reflects a stronger underlying association with a related exposure or is due (at least in part) to residual confounding
Keyword Birth Weight
Ischemic Heart Disease
Follow-up studies
Fetal-Origins Hypothesis
Subsequent Blood Pressure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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