Risk of upper aerodigestive tract cancer associated with smoking with and without concurrent alcohol consumption

Ansary-Moghaddam, Alireza, Huxley, Rachel R., Lam, Tai Hing and Woodward, Mark (2009) Risk of upper aerodigestive tract cancer associated with smoking with and without concurrent alcohol consumption. Mount Sinai Journal of Medicine, 76 4: 392-403. doi:10.1002/msj.20125


Author Ansary-Moghaddam, Alireza
Huxley, Rachel R.
Lam, Tai Hing
Woodward, Mark
Title Risk of upper aerodigestive tract cancer associated with smoking with and without concurrent alcohol consumption
Journal name Mount Sinai Journal of Medicine   Check publisher's open access policy
ISSN 0027-2507
1931-7581
Publication date 2009-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/msj.20125
Volume 76
Issue 4
Start page 392
End page 403
Total pages 12
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Background: Smoking and alcohol are major causal factors for upper aerodigestive tract cancer, but reliable quantification of the combined impact of smoking and alcohol on this cancer and its major subtypes has not been performed.

Methods: A meta-analysis of studies that had published quantitative estimates of smoking and upper aerodigestive tract cancer by January 2007 was performed. Pooled estimates of relative risks were obtained. Publication bias was investigated through funnel plots and corrected if found to be present.

Results: Overall, 85 studies with information on 53,940 individuals with upper aerodigestive tract cancer were included. The pooled estimate for the association between smoking and the risk of this cancer was 3.47 (95% confidence interval, 3.06-3.92). The risk remained elevated for a decade after smoking cessation but declined thereafter. Individuals who both smoked and consumed alcohol had double the risk of upper aerodigestive tract cancer in comparison with those who only smoked: the relative risk was 6.93 (95% confidence interval, 4.99-9.62) for the former and 2.56 (95% confidence interval, 2.20-2.97) for the latter (P < 0.001).

Conclusions: Public health interventions that simultaneously discourage smoking and heavy drinking would have greater benefits than would be expected from those that target only one of these risk factors.
Keyword Alcohol
Cancer
Meta-analysis
Smoking
Upper aerodigestive tract
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
 
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