Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults

Czernichow, Sebastien, Vergnaud, Anne-Claire, Galan, Pilar, Arnaud, Josiane, Favier, Alain, Faure, Henri, Huxley, Rachel, Hercberg, Serge and Ahluwalia, Namanjeet (2009) Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults. American Journal of Clinical Nutrition, 90 2: 329-335. doi:10.3945/ajcn.2009.27635


Author Czernichow, Sebastien
Vergnaud, Anne-Claire
Galan, Pilar
Arnaud, Josiane
Favier, Alain
Faure, Henri
Huxley, Rachel
Hercberg, Serge
Ahluwalia, Namanjeet
Title Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0002-9165
1938-3207
Publication date 2009-08
Year available 2009
Sub-type Article (original research)
DOI 10.3945/ajcn.2009.27635
Volume 90
Issue 2
Start page 329
End page 335
Total pages 7
Place of publication Bethesda, MD United States
Publisher American Society for Nutrition
Collection year 2010
Language eng
Formatted abstract
Background: Limited observational evidence suggests lower antioxidant concentrations in individuals with the metabolic syndrome (MetS); few randomized controlled trials have addressed the effect of multiple antioxidants on the risk of MetS. Objective: The objective was to examine the effect of antioxidant supplementation for 7.5 y on the incidence of MetS and the epidemiologic association between baseline serum antioxidant concentrations and the prospective risk of MetS.

Design:
Adults (n = 5220) participating in the SUpplementation en VItamines et Minéraux AntioXydants (SU.VI.MAX) primary prevention trial were randomly assigned to receive a supplement containing a combination of antioxidants (vitamins C and E, β-carotene, zinc, and selenium) at nutritional doses or a placebo. Subjects were free of MetS at baseline and were followed for 7.5 y.

Results: Antioxidant supplementation for 7.5 y did not affect the risk of MetS. Baseline serum antioxidant concentrations of β-carotene and vitamin C, however, were negatively associated with the risk of MetS; the adjusted odds ratios (and 95% CIs) for the highest compared with the lowest tertile were 0.34 (0.21, 0.53; P for trend = 0.0002) and 0.53 (0.35, 0.80; P for trend = 0.01), respectively. Baseline serum zinc concentrations were positively associated with the risk of developing MetS; the adjusted odds ratio (and 95% CI) for the highest compared with the lowest tertile was 1.81 (1.20, 2.72; P for trend = 0.01).

Conclusions: The experimental finding of no beneficial effects of antioxidant supplementation in a generally well-nourished population is consistent with recent reports of a lack of efficacy of antioxidant supplements. However, the relations observed between the risk of MetS and baseline serum antioxidant concentrations, which probably reflect associations with overall dietary patterns, do support the current recommendations to consume antioxidant-rich foods.
Keyword Nutrition Examination Survey
Randomized Controlled Trials
Elevated Oxidative Stress
Vitamin E
Cardiovascular disease (CVD)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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