Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

Batty, G-D, Li, Q., Huxley, R., Zoungas, S., Taylor, B-A., Neal, B., de Galan, B., Woodward, M., Harrap, S-B, Colagiuri, S., Patel, A. and Chalmers, J. (2013) Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. European Psychiatry, 28 1: 49-52. doi:10.1016/j.eurpsy.2011.07.005


Author Batty, G-D
Li, Q.
Huxley, R.
Zoungas, S.
Taylor, B-A.
Neal, B.
de Galan, B.
Woodward, M.
Harrap, S-B
Colagiuri, S.
Patel, A.
Chalmers, J.
Title Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial
Journal name European Psychiatry   Check publisher's open access policy
ISSN 0924-9338
1778-3585
Publication date 2013-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.eurpsy.2011.07.005
Volume 28
Issue 1
Start page 49
End page 52
Total pages 4
Place of publication Issy les Moulineaux, Cedex, France
Publisher Elsevier Masson
Collection year 2014
Language eng
Formatted abstract
Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

Results:
Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.
Keyword Cognitive decline
Cohort study
Dementia
Oral disease
Alzheimers Disease
Tooth Loss
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
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