Serum and Dietary Magnesium and Incidence of Atrial Fibrillation in Whites and in African Americans - Atherosclerosis Risk in Communities (ARIC) Study

Misialek, Jeffrey R., Lopez, Faye L., Lutsey, Pamela L., Huxley, Rachel R., Peacock, James M., Chen, Lin Y., Soliman, Elsayed Z., Agarwal, Sunil K. and Alonso, Alvaro (2013) Serum and Dietary Magnesium and Incidence of Atrial Fibrillation in Whites and in African Americans - Atherosclerosis Risk in Communities (ARIC) Study. Circulation Journal, 77 2: 323-329. doi:10.1253/circj.CJ-12-0886


Author Misialek, Jeffrey R.
Lopez, Faye L.
Lutsey, Pamela L.
Huxley, Rachel R.
Peacock, James M.
Chen, Lin Y.
Soliman, Elsayed Z.
Agarwal, Sunil K.
Alonso, Alvaro
Title Serum and Dietary Magnesium and Incidence of Atrial Fibrillation in Whites and in African Americans - Atherosclerosis Risk in Communities (ARIC) Study
Journal name Circulation Journal   Check publisher's open access policy
ISSN 1346-9843
Publication date 2013-02
Sub-type Article (original research)
DOI 10.1253/circj.CJ-12-0886
Open Access Status DOI
Volume 77
Issue 2
Start page 323
End page 329
Total pages 7
Place of publication Kyoto-shi, Japan
Publisher Japanese Circulation Society
Collection year 2014
Language eng
Formatted abstract
Background: Low serum magnesium (Mg) has been associated with an increased risk of cardiovascular disease (CVD), including ventricular arrhythmias, but the association between serum or dietary Mg and atrial fibrillation (AF) has not been investigated.

Methods and Results:
A total of 14,290 men and women (75% white; 53% female; mean age, 54 years) free of AF at baseline participating in the Atherosclerosis Risk in Communities study in the United States, were studied. Incident AF cases through 2009 were ascertained from electrocardiograms, hospital discharge codes, and death certificates. Multivariate Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for AF associated with serum and dietary Mg quintiles. Over a median follow-up time of 20.6 years, 1,755 incident AF cases were identified. In multivariate models, lower serum Mg was associated with higher AF risk: compared to individuals in the middle quintile (≥0.80-0.83 mmol/L), the HR (95% CI) of AF in quintiles 1, 2, 4, and 5 were 1.34 (1.16-1.54), 0.99 (0.85-1.16), 1.04 (0.90-1.22), and 1.06 (0.91-1.23), respectively. There was no evidence of significant interactions between serum Mg and sex or race. No association between dietary Mg and AF risk was observed.

Conclusions: Lower serum Mg was associated with a higher AF risk, and this association was not different between whites and African Americans. Dietary Mg was not associated with AF risk.
Keyword Atrial fibrillation
Dietary magnesium
Serum magnesium
Coronary heart disease
Artery Bypass Surgery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
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