The role of endocannabinoids in pregnancy

Chan, Hsiu-Wen, McKirdy, Natalie C., Peiris, Hassendrini N., Rice, Gregory E. and Mitchell, Murray D. (2013) The role of endocannabinoids in pregnancy. Reproduction, 146 3: R101-R109. doi:10.1530/REP-12-0508

Author Chan, Hsiu-Wen
McKirdy, Natalie C.
Peiris, Hassendrini N.
Rice, Gregory E.
Mitchell, Murray D.
Title The role of endocannabinoids in pregnancy
Journal name Reproduction   Check publisher's open access policy
ISSN 1470-1626
Publication date 2013-09-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1530/REP-12-0508
Volume 146
Issue 3
Start page R101
End page R109
Total pages 9
Place of publication Woodlands, Bristol, United Kingdom
Publisher BioScientifica
Collection year 2014
Language eng
Formatted abstract
Endocannabinoids are a family of lipid signalling molecules. As with prostaglandins (PGs), endocannabinoids are derived from polyunsaturated fatty acids and affect cell function via receptor-mediated mechanisms. They also bind to PG receptors, although at a lower affinity. The endocannabinoid network is regulated in pregnancy from embryo development to labour onset. Even small changes in endocannabinoid exposure can retard embryo development and affect implantation success. There is now compelling evidence that aberrant expression of factors involved in the endocannabinoid pathway in the placenta and circulating lymphocytes results in spontaneous miscarriage and poor pregnancy outcomes. It is likely that competition between endocannabinoids, PGs and other similar lipids ultimately determines how phospholipid/fatty acid substrates are metabolised and, thus, the balance between the uterotonic and tocolytic activities. We, therefore, hypothesise that endocannabinoid profiles may be used as a biomarker to predict and/or identify spontaneous labour onset.
Keyword Acid amide hydrolase
Preimplantation mouse embryo
Tandem mass-spectrometry
High anandamide levels
Cannabinoid receptor
Ectopic pregnancy
Fetal membranes
CB1 receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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