Prevalence of anisometropia and its association with refractive error and amblyopia in preschool children

Afsari, Sonia, Rose, Kathryn A., Gole, Glen A., Philip, Krupa, Leone, Jody F., French, Amanda and Mitchell, Paul (2013) Prevalence of anisometropia and its association with refractive error and amblyopia in preschool children. British Journal of Ophthalmology, 97 9: 1095-1099. doi:10.1136/bjophthalmol-2012-302637

Author Afsari, Sonia
Rose, Kathryn A.
Gole, Glen A.
Philip, Krupa
Leone, Jody F.
French, Amanda
Mitchell, Paul
Title Prevalence of anisometropia and its association with refractive error and amblyopia in preschool children
Journal name British Journal of Ophthalmology   Check publisher's open access policy
ISSN 0007-1161
Publication date 2013-09
Sub-type Article (original research)
DOI 10.1136/bjophthalmol-2012-302637
Volume 97
Issue 9
Start page 1095
End page 1099
Total pages 5
Place of publication London, United Kingdom
Publisher B M J Group
Collection year 2014
Language eng
Formatted abstract
Aim To determine the age and ethnicity-specific prevalence of anisometropia in Australian preschool-aged children and to assess in this population-based study the risk of anisometropia with increasing ametropia levels and risk of amblyopia with increasing anisometropia.

Methods A total 2090 children (aged 6–72 months) completed detailed eye examinations in the Sydney Paediatric Eye Disease Study, including cycloplegic refraction, and were included. Refraction was measured using a Canon RK-F1 autorefractor, streak retinoscopy and/or the Retinomax K-Plus 2 autorefractor. Anisometropia was defined by the spherical equivalent (SE) difference, and plus cylinder difference for any cylindrical axis between eyes.

Results The overall prevalence of SE and cylindrical anisometropia ≥1.0 D were 2.7% and 3.0%, for the overall sample and in children of European-Caucasian ethnicity, 3.2%, 1.9%; East-Asian 1.7%, 5.2%; South-Asian 2.5%, 3.6%; Middle-Eastern ethnicities 2.2%, 3.3%, respectively. Anisometropia prevalence was lower or similar to that in the Baltimore Pediatric Eye Disease Study, Multi-Ethnic Pediatric Eye Disease Study and the Strabismus, Amblyopia and Refractive error in Singapore study. Risk (OR) of anisometropic amblyopia with ≥1.0 D of SE and cylindrical anisometropia was 12.4 (CI 4.0 to 38.4) and 6.5 (CI 2.3 to 18.7), respectively. We found an increasing risk of anisometropia with higher myopia ≥−1.0 D, OR 61.6 (CI 21.3 to 308), hyperopia > +2.0 D, OR 13.6 (CI 2.9 to 63.6) and astigmatism ≥1.5 D, OR 30.0 (CI 14.5 to 58.1).

Conclusions In this preschool-age population-based sample, anisometropia was uncommon with inter-ethnic differences in cylindrical anisometropia prevalence. We also quantified the rising risk of amblyopia with increasing SE and cylindrical anisometropia, and present the specific levels of refractive error and associated increasing risk of anisometropia.
Keyword Child health (paediatrics)
Public health
Population based sample
Blue Mountains Eye Study
Astigmatic children
Older population
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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