Association of adiposity genetic variants with menarche timing in 92,105 women of European descent

Fernández-Rhodes, Lindsay, Demerath, Ellen W., Cousminer, Diana L., Tao, Ran, Dreyfus, Jill G., Esko, Tõnu, Smith, Albert V., Gudnason, Vilmundur, Harris, Tamara B., Launer, Lenore, McArdle, Patrick F., Yerges-Armstrong, Laura M., Elks, Cathy E., Strachan, David P., Kutalik, Zoltán, Vollenweider, Peter, Feenstra, Bjarke, Boyd, Heather A., Metspalu, Andres, Mihailov, Evelin, Broer, Linda, Zillikens, M. Carola, Oostra, Ben, van Duijn, Cornelia M., Lunetta, Kathryn L., Perry, John R. B., Murray, Anna, Koller, Daniel L., Lai, Dongbing, Corre, Tanguy, Toniolo, Daniela, Albrecht, Eva, Stöckl, Doris, Grallert, Harald, Gieger, Christian, Hayward, Caroline, Polasek, Ozren, Rudan, Igor, Wilson, James F., He, Chunyan, Kraft, Peter, Hu, Frank B., Hunter, David J., Hottenga, Jouke-Jan, Willemsen, Gonneke, Boomsma, Dorret I., Byrne, Enda M., Martin, Nicholas G., Montgomery, Grant W., Warrington, Nicole M., Pennell, Craig E., Stolk, Lisette, Visser, Jenny A., Hofman, Albert, Uitterlinden, André G., Rivadeneira, Fernando, Lin, Peng, Fisher, Sherri L., Bierut, Laura J., Crisponi, Laura, Porcu, Eleonora, Mangino, Massimo, Zhai, Guangju, Spector, Tim D., Buring, Julie E., Rose, Lynda M., Ridker, Paul M., Poole, Charles, Hirschhorn, Joel N., Murabito, Joanne M., Chasman, Daniel I., Widen, Elisabeth, North, Kari E., Ong, Ken K. and Franceschini, Nora (2013) Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. American Journal of Epidemiology, 178 3: 451-460. doi:10.1093/aje/kws473

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Author Fernández-Rhodes, Lindsay
Demerath, Ellen W.
Cousminer, Diana L.
Tao, Ran
Dreyfus, Jill G.
Esko, Tõnu
Smith, Albert V.
Gudnason, Vilmundur
Harris, Tamara B.
Launer, Lenore
McArdle, Patrick F.
Yerges-Armstrong, Laura M.
Elks, Cathy E.
Strachan, David P.
Kutalik, Zoltán
Vollenweider, Peter
Feenstra, Bjarke
Boyd, Heather A.
Metspalu, Andres
Mihailov, Evelin
Broer, Linda
Zillikens, M. Carola
Oostra, Ben
van Duijn, Cornelia M.
Lunetta, Kathryn L.
Perry, John R. B.
Murray, Anna
Koller, Daniel L.
Lai, Dongbing
Corre, Tanguy
Toniolo, Daniela
Albrecht, Eva
Stöckl, Doris
Grallert, Harald
Gieger, Christian
Hayward, Caroline
Polasek, Ozren
Rudan, Igor
Wilson, James F.
He, Chunyan
Kraft, Peter
Hu, Frank B.
Hunter, David J.
Hottenga, Jouke-Jan
Willemsen, Gonneke
Boomsma, Dorret I.
Byrne, Enda M.
Martin, Nicholas G.
Montgomery, Grant W.
Warrington, Nicole M.
Pennell, Craig E.
Stolk, Lisette
Visser, Jenny A.
Hofman, Albert
Uitterlinden, André G.
Rivadeneira, Fernando
Lin, Peng
Fisher, Sherri L.
Bierut, Laura J.
Crisponi, Laura
Porcu, Eleonora
Mangino, Massimo
Zhai, Guangju
Spector, Tim D.
Buring, Julie E.
Rose, Lynda M.
Ridker, Paul M.
Poole, Charles
Hirschhorn, Joel N.
Murabito, Joanne M.
Chasman, Daniel I.
Widen, Elisabeth
North, Kari E.
Ong, Ken K.
Franceschini, Nora
Title Association of adiposity genetic variants with menarche timing in 92,105 women of European descent
Journal name American Journal of Epidemiology   Check publisher's open access policy
ISSN 0002-9262
Publication date 2013-08-01
Sub-type Article (original research)
DOI 10.1093/aje/kws473
Open Access Status
Volume 178
Issue 3
Start page 451
End page 460
Total pages 10
Place of publication Cary, NC, United States
Publisher Oxford University Press
Collection year 2014
Language eng
Formatted abstract
Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)2), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970–2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 9–17 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development.
Keyword Adiposity
Body mass index
Genetic association studies
Waist circumference
Waist:hip ratio
Womens health
Genome-wide association
Body-mass index
Waist circumference
Sequence variants
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
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