In the spotlight: myeloid TGF-beta responsiveness promotes metastases

Souza-Fonseca-Guimaraes, Fernando and Smyth, Mark J. (2013) In the spotlight: myeloid TGF-beta responsiveness promotes metastases. Cancer Discovery, 3 8: 846-848. doi:10.1158/2159-8290.CD-13-0271

Author Souza-Fonseca-Guimaraes, Fernando
Smyth, Mark J.
Title In the spotlight: myeloid TGF-beta responsiveness promotes metastases
Formatted title
In the spotlight: myeloid TGF-β responsiveness promotes metastases
Journal name Cancer Discovery   Check publisher's open access policy
ISSN 2159-8274
Publication date 2013-08
Sub-type Editorial
DOI 10.1158/2159-8290.CD-13-0271
Open Access Status DOI
Volume 3
Issue 8
Start page 846
End page 848
Total pages 3
Place of publication Philadelphia, PA, United States
Publisher American Association for Cancer Research
Collection year 2014
Language eng
Formatted abstract
Tumor-induced immune suppression is a major impediment to many potentially effective cancer therapies. TGF-β has previously been described as having both tumor-promoting and tumor-suppressive characteristics. In this issue of Cancer Discovery, Pang and colleagues show that myeloid-specific TGF-β signaling is a critical mediator in tumor metastasis. These findings point to a more specific means to reduce cancer immunosuppression, prevent metastasis, and minimize treatment-related adverse events.
Keyword Growth-factor
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collections: Non HERDC
School of Medicine Publications
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Created: Sun, 08 Sep 2013, 00:11:29 EST by System User on behalf of School of Medicine