Daytime fluctuation of intraocular pressure in patients with primary angle-closure glaucoma after trabeculectomy

Liang, Yuan Bo, Xie, Cong, Meng, Hai Lin, Feng, Mei Yan, Fan, Su Jie, Liu, Luo Ru, Xie, Li Lian, Chao, Jia, Wang, Xing, Wang, Ning Li and Thomas, Ravi (2013) Daytime fluctuation of intraocular pressure in patients with primary angle-closure glaucoma after trabeculectomy. Journal of Glaucoma, 22 5: 349-354. doi:10.1097/IJG.0b013e31826a7dd5


Author Liang, Yuan Bo
Xie, Cong
Meng, Hai Lin
Feng, Mei Yan
Fan, Su Jie
Liu, Luo Ru
Xie, Li Lian
Chao, Jia
Wang, Xing
Wang, Ning Li
Thomas, Ravi
Title Daytime fluctuation of intraocular pressure in patients with primary angle-closure glaucoma after trabeculectomy
Journal name Journal of Glaucoma   Check publisher's open access policy
ISSN 1057-0829
1536-481X
Publication date 2013-06-01
Sub-type Article (original research)
DOI 10.1097/IJG.0b013e31826a7dd5
Volume 22
Issue 5
Start page 349
End page 354
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2014
Language eng
Formatted abstract
Purpose: To evaluate the daytime fluctuation of intraocular pressure (IOP) in patients with primary angle-closure glaucoma (PACG) after trabeculectomy.

Participants and Methods: A total of 176 patients with PACG participated in a clinical trial of trabeculectomy with or without releasable sutures. Applanation IOP was measured at 5, 7, and 10 AM, and 2, 6, and 10 PM at 3 months posttrabeculectomy. We documented the mean, peak, and trough IOPs, determined the fluctuation of daytime IOP, and explored the associations of IOP fluctuation with baseline factors.

Results: IOP measurements were obtained in 173 patients. The mean daytime IOP was 13.2±3.7mm Hg; mean peak IOP 15.1±4.1mm Hg, mean trough IOP 11.3±3.5mm Hg, and mean fluctuation 3.8±2.1mm Hg. Fluctuation was positively correlated with peak (r=0.528, R 2=0.28, P<0.001) and mean IOP (r=0.278, R2=0.08, P<0.001), but not with the trough IOP (r=0.015, P=0.843). Fluctuation was lower with extent of bleb (0.6mm Hg/unit increase in extent; 95% CI, 0.1-1.2mm Hg) and in blebs with microcysts (1.1mm Hg less fluctuation; 95% CI, 0.2-1.9 mm Hg). Fluctuation was not associated with sex, age, baseline IOP, extent of peripheral anterior synechia or number of glaucoma medications before surgery, mean deviation of the visual field, vertical cup:disc ratio, or the use of releasable sutures.

Conclusions: The mean fluctuation of daytime IOP after trabeculectomy for PACG was about 4mm Hg. The fluctuation was positively associated with higher peak and mean IOP and negatively associated with extent of bleb and presence of microcysts.
Keyword Intraocular pressure
Primary angle-closure glaucoma
Trabeculectomy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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