'Food addiction' and its association with a dopaminergic multilocus genetic profile

Davis, Caroline, Loxton, Natalie J., Levitan, Robert D., Kaplan, Allan S., Carter, Jacqueline C. and Kennedy, James L. (2013) 'Food addiction' and its association with a dopaminergic multilocus genetic profile. Physiology and Behavior, 118 63-69. doi:10.1016/j.physbeh.2013.05.014

Author Davis, Caroline
Loxton, Natalie J.
Levitan, Robert D.
Kaplan, Allan S.
Carter, Jacqueline C.
Kennedy, James L.
Title 'Food addiction' and its association with a dopaminergic multilocus genetic profile
Journal name Physiology and Behavior   Check publisher's open access policy
ISSN 0031-9384
Publication date 2013-06
Sub-type Article (original research)
DOI 10.1016/j.physbeh.2013.05.014
Volume 118
Start page 63
End page 69
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Background: Our objective was to employ a novel genetic methodology - whereby functional variants of the dopamine pathway were aggregated to reflect a polygenic liability - in the study of food addiction. We anticipated that the composite index of elevated dopamine signaling (a multilocus genetic profile score [MLGP]) would distinguish those with a designation of food addiction (according to the Yale Food Addiction Scale [YFAS] criteria), and age and weight equivalent controls. Our second aim was to assess whether this index was positively associated with eating-related sub-phenotypes of food addiction (e.g. binge eating and food cravings).

Methods: Adults (n= 120) recruited from the community were solicited for an overeating/overweight study. Eating-behavior questionnaires were completed and a blood sample was taken for genotyping.

Results and conclusions: The YFAS identified 21 participants with food addiction. As predicted, the MLGP score was higher in those with YFAS-diagnosed food addiction, and it correlated positively with binge eating, food cravings, and emotional overeating. We then tested a multiple-mediation model proposing that reward-driven overeating facilitates the relationship between the MLGP score and food addiction. The model was statistically significant, supporting the view that the relationship between a composite genetic index of dopamine signaling and food addiction is mediated by certain aspects of reward-responsive overeating.
Keyword Food addiction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Psychology Publications
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