Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment

Leire, Emma, Olson, Josh, Isaacs, Hart, Nizet, Victor and Hollands, Andrew (2013) Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment. Journal of Inflammation, 10 28: 1-6. doi:10.1186/1476-9255-10-28


Author Leire, Emma
Olson, Josh
Isaacs, Hart
Nizet, Victor
Hollands, Andrew
Title Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment
Journal name Journal of Inflammation   Check publisher's open access policy
ISSN 1476-9255
Publication date 2013-08
Sub-type Article (original research)
DOI 10.1186/1476-9255-10-28
Open Access Status DOI
Volume 10
Issue 28
Start page 1
End page 6
Total pages 6
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2014
Language eng
Formatted abstract
Background Hypoxia inducible factor-1 (HIF-1) is a major regulator of the cellular adaption to low oxygen stress and the innate immune function of myeloid cells. Treatment with the novel HIF-1 stabilizing drug AKB-4924 has been shown to enhance the bactericidal activity of keratinocytes as well as phagocytic cells. In this study, we sought to investigate the effect of pharmacological boosting of HIF-1 with AKB-4924 in keratinocytes and their contribution to the innate immune response.

Findings Treatment with the novel HIF-1 stabilizing drug AKB-4924 can increase keratinocyte production of pro-inflammatory cytokines in vitro and enhance neutrophil recruitment in vivo.

Conclusions HIF plays an important role in cytokine production by keratinocytes and in neutrophil recruitment to the skin. The HIF-boosting drug AKB-4924 has the potential to enhance the immune response even in the complex environment of bacterial skin infections.
Keyword Hypoxia-inducible factor
HIF
Cytokine
Keratinocyte
Neutrophil recruitment
Inflammation
Bactericidal capacity
HIF-1-alpha
Activation
Phagocytes
Expression
Infection
Defense
HIF
HIF-1α
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
 
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