Tactile interactions lead to coherent motion and enhanced chemotaxis of migrating cells

Coburn, Luke, Cerone, Luca, Torney, Colin, Couzin, Iain D. and Neufeld, Zoltan (2013) Tactile interactions lead to coherent motion and enhanced chemotaxis of migrating cells. Physical Biology, 10 4: 046002.1-046002.8. doi:10.1088/1478-3975/10/4/046002


Author Coburn, Luke
Cerone, Luca
Torney, Colin
Couzin, Iain D.
Neufeld, Zoltan
Title Tactile interactions lead to coherent motion and enhanced chemotaxis of migrating cells
Journal name Physical Biology   Check publisher's open access policy
ISSN 1478-3967
1478-3975
Publication date 2013-08-01
Sub-type Article (original research)
DOI 10.1088/1478-3975/10/4/046002
Volume 10
Issue 4
Start page 046002.1
End page 046002.8
Total pages 8
Place of publication Bristol, United Kingdom
Publisher Institute of Physics Publishing
Collection year 2014
Language eng
Abstract When motile cells come into contact with one another their motion is often considerably altered. In a process termed contact inhibition of locomotion (CIL) cells reshape and redirect their movement as a result of cell-cell contact. Here we describe a mathematical model that demonstrates that CIL alone is sufficient to produce coherent, collective cell migration. Our model illustrates a possible mechanism behind collective cell migration that is observed, for example, in neural crest cells during development, and in metastasizing cancer cells. We analyse the effects of varying cell density and shape on the alignment patterns produced and the transition to coherent motion. Finally, we demonstrate that this process may have important functional consequences by enhancing the accuracy and robustness of the chemotactic response, and factors such as cell shape and cell density are more significant determinants of migration accuracy than the individual capacity to detect environmental gradients.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
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