Pattern recognition receptor function in neutrophils

Thomas, Christina J. and Schroder, Kate (2013) Pattern recognition receptor function in neutrophils. Trends in Immunology, 34 7: 317-328. doi:10.1016/j.it.2013.02.008


Author Thomas, Christina J.
Schroder, Kate
Title Pattern recognition receptor function in neutrophils
Journal name Trends in Immunology   Check publisher's open access policy
ISSN 1471-4906
1471-4981
Publication date 2013-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.it.2013.02.008
Volume 34
Issue 7
Start page 317
End page 328
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Abstract Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR) signaling field. However, interest in neutrophil biology has been revitalized by emerging roles for neutrophils in promoting protective and pathogenic T helper (Th)17-driven immune responses and in orchestrating innate and adaptive immunity via cytokine/chemokine production. Although it was originally assumed that neutrophils are transcriptionally inert and their short lifespan limits their ability to respond to PRR agonists, the past 5 years has seen tremendous advances in neutrophil PRR signaling that have shifted this paradigm. Here, we review recent findings that demonstrate that neutrophils express a broad repertoire of PRRs, respond dynamically to their stimulation during infection and inflammation, and that neutrophil PRRs are key regulators of in vivo host immune responses.
Keyword Toll-like receptor
C-type lectin receptor
NOD-like receptor
Inflammasome
Cytokines
Granulocytes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 40 times in Scopus Article | Citations
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