Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses

Ferro, Vito (2013) Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses. Expert Opinion on Therapeutic Targets, 17 8: 965-975. doi:10.1517/14728222.2013.811491

Author Ferro, Vito
Title Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses
Journal name Expert Opinion on Therapeutic Targets   Check publisher's open access policy
ISSN 1472-8222
Publication date 2013-08
Year available 2013
Sub-type Article (original research)
DOI 10.1517/14728222.2013.811491
Volume 17
Issue 8
Start page 965
End page 975
Total pages 11
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2014
Language eng
Formatted abstract
Introduction: Heparan sulfate (HS) is a polysaccharide that is ubiquitously expressed on the cell surface and in the extracellular matrix and interacts with a wide variety of proteins to mediate numerous biological and pathological functions, including inflammation.

Areas covered: The structural diversity and the multiple biological roles of HS in inflammation are discussed. HS is involved in the recruitment and attachment of leukocytes to the inflamed epithelium, the activation of chemokines and the transmigration of leukocytes to the underlying target tissue. The endoglycosidase heparanase plays a key role in the above processes via the degradation of HS. HS mimetics that inhibit heparanase and block HS-binding proteins have been shown to inhibit inflammation in multiple animal models.

Expert opinion: HS plays important roles in many stages of the inflammation process, in particular the regulation of leukocyte extravasation. Compounds that can inhibit HS-protein interactions thus have considerable potential as anti-inflammatory therapeutics capable of simultaneously interfering with multiple steps of the inflammation process. There are a number of such compounds in various stages of clinical development for cancer, which should also find applications in inflammatory illnesses.
Keyword Extravasation
Heparan sulfate
Heparin mimetics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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