Interaction of genotype and environment: effect of strain and housing conditions on cognitive behavior in rodent models of schizophrenia

Turner, Karly M. and Burne, Thomas H. J. (2013) Interaction of genotype and environment: effect of strain and housing conditions on cognitive behavior in rodent models of schizophrenia. Frontiers in Behavioral Neuroscience, 7 JUL: . doi:10.3389/fnbeh.2013.00097


Author Turner, Karly M.
Burne, Thomas H. J.
Title Interaction of genotype and environment: effect of strain and housing conditions on cognitive behavior in rodent models of schizophrenia
Journal name Frontiers in Behavioral Neuroscience   Check publisher's open access policy
ISSN 1662-5153
Publication date 2013-07
Year available 2013
Sub-type Article (original research)
DOI 10.3389/fnbeh.2013.00097
Open Access Status DOI
Volume 7
Issue JUL
Total pages 7
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2014
Language eng
Formatted abstract
Schizophrenia is associated with many genetic and environmental risk factors and there is growing evidence that the interactions between genetic and environmental 'hits' are critical for disease onset. Animal models of schizophrenia have traditionally used specific strain and housing conditions to test potential risk factors. As the field moves towards testing gene (G) x environment (E) interactions the impact of these choices should be considered. Given the surge of research focused on cognitive deficits, we have examined studies of cognition in rodents from the perspective of GxE interactions, in which strain or housing manipulations have been varied. Behaviour is clearly altered by these factors, yet few animal models of schizophrenia have investigated cognitive deficits using different strain and housing conditions. It is important to recognise the large variation in behaviour observed when using different strain and housing combinations because GxE interactions may mask or exacerbate cognitive outcomes. Further consideration will improve our understanding of GxE interactions and the underlying neurobiology of cognitive impairments in neuropsychiatric disorders
Keyword Background strain
Cognition
Enriched environment
Schizophrenia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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