Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China

Wang, Yongbo, Dai, Zhangyan, Cheng, Han, Liu, Zexian, Pan, Zhicheng, Deng, Wankun, Gao, Tianshun, Li, Xiaotong, Yao, Yuangen, Ren, Jian and Xue, Yu (2013) Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China. Scientific Reports, 3 2318.1-2318.10. doi:10.1038/srep02318

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Author Wang, Yongbo
Dai, Zhangyan
Cheng, Han
Liu, Zexian
Pan, Zhicheng
Deng, Wankun
Gao, Tianshun
Li, Xiaotong
Yao, Yuangen
Ren, Jian
Xue, Yu
Title Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2013-07
Sub-type Article (original research)
DOI 10.1038/srep02318
Open Access Status DOI
Volume 3
Start page 2318.1
End page 2318.10
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Abstract Recently, a highly dangerous bird flu has infected over 130 patients in China, and the outbreak was attributed to a novel avian-origin H7N9 virus. Here, we performed a systematic analysis of the virus. We clarified the controversial viewpoint on neuraminidase (NA) origin and confirmed it was reassorted from Korean wild birds with higher confidence, whereas common ancestors of pathogenic H7N9 genes existed only one or two years ago. Further analysis of NA sequences suggested that most variations are not drug resistant and current drugs are still effective for the therapy. We also identified a potentially optimal 9-mer epitope, which can be helpful for vaccine development. The interaction of hemagglutinin (HA) and human receptor analog was confirmed by structural modeling, while NA might influence cellular processes through a PDZ-binding motif. A simplified virus infection model was proposed. Taken together, our studies provide a better understanding of the newly reassorted H7N9 viruses.
Keyword Molecular Evolutionary Genetics
Human Infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 01 Sep 2013, 00:11:45 EST by System User on behalf of School of Chemistry & Molecular Biosciences