The role of lifestyle change in the prevention and treatment of NAFLD

Centis, Elena, Marzocchi, Rebecca, Suppini, Alessandro, Grave, Riccardo Dalle, Villanova, Nicola, Hickman, Ingrid J. and Marchesini, Giulio (2013) The role of lifestyle change in the prevention and treatment of NAFLD. Current Pharmaceutical Design, 19 29: 5270-5279. doi:10.2174/1381612811319290008

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Centis, Elena
Marzocchi, Rebecca
Suppini, Alessandro
Grave, Riccardo Dalle
Villanova, Nicola
Hickman, Ingrid J.
Marchesini, Giulio
Title The role of lifestyle change in the prevention and treatment of NAFLD
Journal name Current Pharmaceutical Design   Check publisher's open access policy
ISSN 1381-6128
Publication date 2013-09
Sub-type Article (original research)
DOI 10.2174/1381612811319290008
Open Access Status
Volume 19
Issue 29
Start page 5270
End page 5279
Total pages 10
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2014
Language eng
Formatted abstract
Healthy habits in terms of food intake and physical activity are first-line approach to prevention and treatment of nonalcoholic fatty liver disease, but difficulties arise in turning attempts into practice. Independently of the specific role of individual nutrients, not universally proven, overweight, obesity and diabetes are the specific conditions most frequently associated with hepatic fat accumulation. Accordingly, weight loss is mandatory in the majority of patients; this can be achieved by dietary restriction, but is rarely maintained in the long-term. Physical activity programs, both aerobic and resistance exercise may improve cardiorespiratory fitness, reduce the multiple conditions associated with the metabolic syndrome and help weight loss maintenance. However, motivating sedentary individuals to move is difficult and is favored by structured programs carried out along the lines of cognitive-behavior therapy. The role of behavior therapy is now supported by pilot studies, observational studies and finally by a randomized controlled study with histological outcomes. In the future, behavior interventions might be supported by important technological advances, such as smart phone technology and webbased platforms to facilitate interactive engagement amongst patients and with their health care providers. Lifestyle programs must also incorporate methods of overcoming barriers to accessing health service, engaging with workplace health programs and linking with community attempts to improve public health.
Keyword Nonalcoholic fatty liver disease
Metabolic syndrome
Physical activity
Cardiovascular disease
Behavior therapy
Fatty liver-disease
Type-2 diabetes-mellitus
Body-mass index
Moderate weight-reduction
NIH-AARP cohort
Nonalcoholic steatohepatitis
Cardiorespiratory fitness
Alanine aminotransferase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Human Movement and Nutrition Sciences Publications
UQ Diamantina Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 01 Sep 2013, 00:09:15 EST by System User on behalf of School of Human Movement and Nutrition Sciences